Keren Yizhak

Dr.

    20102025

    Research activity per year

    Filter
    Article

    Search results

    • 2025

      A metabolic switch to the pentose-phosphate pathway induces radiation resistance in pancreatic cancer

      Shimoni-Sebag, A., Abramovich, I., Agranovich, B., Massri, R., Stossel, C., Atias, D., Raites-Gurevich, M., Yizhak, K., Golan, T., Gottlieb, E. & Lawrence, Y. R., Jan 2025, In: Radiotherapy and Oncology. 202, 110606.

      Research output: Contribution to journalArticlepeer-review

    • 2024

      Human lung cancer harbors spatially organized stem-immunity hubs associated with response to immunotherapy

      Chen, J. H., Nieman, L. T., Spurrell, M., Jorgji, V., Elmelech, L., Richieri, P., Xu, K. H., Madhu, R., Parikh, M., Zamora, I., Mehta, A., Nabel, C. S., Freeman, S. S., Pirl, J. D., Lu, C., Meador, C. B., Barth, J. L., Sakhi, M., Tang, A. L. & Sarkizova, S. & 17 others, Price, C., Fernandez, N. F., Emanuel, G., He, J., Van Raay, K., Reeves, J. W., Yizhak, K., Hofree, M., Shih, A., Sade-Feldman, M., Boland, G. M., Pelka, K., Aryee, M. J., Mino-Kenudson, M., Gainor, J. F., Korsunsky, I. & Hacohen, N., 19 Mar 2024, In: Nature Immunology. 25, 4, p. 644-658 15 p.

      Research output: Contribution to journalArticlepeer-review

    • 2023

      Metabolic predictors of response to immune checkpoint blockade therapy

      Shorer, O. & Yizhak, K., 17 Nov 2023, In: iScience. 26, 11, p. 108188 108188.

      Research output: Contribution to journalArticlepeer-review

      Open Access
    • Targeting TBK1 to overcome resistance to cancer immunotherapy

      Sun, Y., Revach, O. Y., Anderson, S., Kessler, E. A., Wolfe, C. H., Jenney, A., Mills, C. E., Robitschek, E. J., Davis, T. G. R., Kim, S., Fu, A., Ma, X., Gwee, J., Tiwari, P., Du, P. P., Sindurakar, P., Tian, J., Mehta, A., Schneider, A. M. & Yizhak, K. & 39 others, Sade-Feldman, M., LaSalle, T., Sharova, T., Xie, H., Liu, S., Michaud, W. A., Saad-Beretta, R., Yates, K. B., Iracheta-Vellve, A., Spetz, J. K. E., Qin, X., Sarosiek, K. A., Zhang, G., Kim, J. W., Su, M. Y., Cicerchia, A. M., Rasmussen, M. Q., Klempner, S. J., Juric, D., Pai, S. I., Miller, D. M., Giobbie-Hurder, A., Chen, J. H., Pelka, K., Frederick, D. T., Stinson, S., Ivanova, E., Aref, A. R., Paweletz, C. P., Barbie, D. A., Sen, D. R., Fisher, D. E., Corcoran, R. B., Hacohen, N., Sorger, P. K., Flaherty, K. T., Boland, G. M., Manguso, R. T. & Jenkins, R. W., Mar 2023, In: Nature. 615, 7950, p. 158-167 10 p.

      Research output: Contribution to journalArticlepeer-review

    • 2022

      Combined tumor and immune signals from genomes or transcriptomes predict outcomes of checkpoint inhibition in melanoma

      Freeman, S. S., Sade-Feldman, M., Kim, J., Stewart, C., Gonye, A. L. K., Ravi, A., Arniella, M. B., Gushterova, I., LaSalle, T. J., Blaum, E. M., Yizhak, K., Frederick, D. T., Sharova, T., Leshchiner, I., Elagina, L., Spiro, O. G., Livitz, D., Rosebrock, D., Aguet, F. & Carrot-Zhang, J. & 19 others, Ha, G., Lin, Z., Chen, J. H., Barzily-Rokni, M., Hammond, M. R., Vitzthum von Eckstaedt, H. C., Blackmon, S. M., Jiao, Y. J., Gabriel, S., Lawrence, D. P., Duncan, L. M., Stemmer-Rachamimov, A. O., Wargo, J. A., Flaherty, K. T., Sullivan, R. J., Boland, G. M., Meyerson, M., Getz, G. & Hacohen, N., 15 Feb 2022, In: Cell Reports Medicine. 3, 2, p. 100500 100500.

      Research output: Contribution to journalArticlepeer-review

      Open Access
    • Estimating tumor mutational burden from RNA-sequencing without a matched-normal sample

      Katzir, R., Rudberg, N. & Yizhak, K., 2 Jun 2022, In: Nature Communications. 13, 1, 3092.

      Research output: Contribution to journalArticlepeer-review

      Open Access
    • חישוב מציל חיים

      ⁨יצחק, ק.⁩, ⁨קציר, ר.⁩ & ⁨רודברג, נ.⁩, 2022, In: הטכניון. p. 22-23 2 p.

      Research output: Contribution to journalArticle

      Open Access
    • 2021

      Alternative splicing of the inhibitory immune checkpoint receptor SLAMF6 generates a dominant positive form, boosting T-cell effector functions

      Hajaj, E., Zisman, E., Tzaban, S., Merims, S., Cohen, J., Klein, S., Frankenburg, S., Sade-Feldman, M., Tabach, Y., Yizhak, K., Navon, A., Stepensky, P., Hacohen, N., Peretz, T., Veillette, A., Karni, R., Eisenberg, G. & Lotem, M., Jun 2021, In: Cancer immunology research. 9, 6, p. 637-650 14 p.

      Research output: Contribution to journalArticlepeer-review

      Open Access
    • 2020

      B cells and tertiary lymphoid structures promote immunotherapy response

      Helmink, B. A., Reddy, S. M., Gao, J., Zhang, S., Basar, R., Thakur, R., Yizhak, K., Sade-Feldman, M., Blando, J., Han, G., Gopalakrishnan, V., Xi, Y., Zhao, H., Amaria, R. N., Tawbi, H. A., Cogdill, A. P., Liu, W., LeBleu, V. S., Kugeratski, F. G. & Patel, S. & 40 others, Davies, M. A., Hwu, P., Lee, J. E., Gershenwald, J. E., Lucci, A., Arora, R., Woodman, S., Keung, E. Z., Gaudreau, P. O., Reuben, A., Spencer, C. N., Burton, E. M., Haydu, L. E., Lazar, A. J., Zapassodi, R., Hudgens, C. W., Ledesma, D. A., Ong, S. F., Bailey, M., Warren, S., Rao, D., Krijgsman, O., Rozeman, E. A., Peeper, D., Blank, C. U., Schumacher, T. N., Butterfield, L. H., Zelazowska, M. A., McBride, K. M., Kalluri, R., Allison, J., Petitprez, F., Fridman, W. H., Sautès-Fridman, C., Hacohen, N., Rezvani, K., Sharma, P., Tetzlaff, M. T., Wang, L. & Wargo, J. A., 15 Jan 2020, In: Nature. 577, 7791, p. 549-555 7 p.

      Research output: Contribution to journalArticlepeer-review

      Open Access
    • 2019

      PD-1 blockade in subprimed CD8 cells induces dysfunctional PD-1+CD38hi cells and anti-PD-1 resistance

      Verma, V., Shrimali, R. K., Ahmad, S., Dai, W., Wang, H., Lu, S., Nandre, R., Gaur, P., Lopez, J., Sade-Feldman, M., Yizhak, K., Bjorgaard, S. L., Flaherty, K. T., Wargo, J. A., Boland, G. M., Sullivan, R. J., Getz, G., Hammond, S. A., Tan, M. & Qi, J. & 8 others, Wong, P., Merghoub, T., Wolchok, J., Hacohen, N., Janik, J. E., Mkrtichyan, M., Gupta, S. & Khleif, S. N., 1 Sep 2019, In: Nature Immunology. 20, 9, p. 1231-1243 13 p.

      Research output: Contribution to journalArticlepeer-review

      Open Access
    • RNA sequence analysis reveals macroscopic somatic clonal expansion across normal tissues

      Yizhak, K., Aguet, F., Kim, J., Hess, J. M., Kübler, K., Grimsby, J., Frazer, R., Zhang, H., Haradhvala, N. J., Rosebrock, D., Livitz, D., Li, X., Arich-Landkof, E., Shoresh, N., Stewart, C., Segrè, A. V., Branton, P. A., Polak, P., Ardlie, K. G. & Getz, G., 7 Jun 2019, In: Science. 364, 6444, eaaw0726.

      Research output: Contribution to journalArticlepeer-review

      Open Access
    • 2018

      Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma

      Sade-Feldman, M., Yizhak, K., Bjorgaard, S. L., Ray, J. P., de Boer, C. G., Jenkins, R. W., Lieb, D. J., Chen, J. H., Frederick, D. T., Barzily-Rokni, M., Freeman, S. S., Reuben, A., Hoover, P. J., Villani, A. C., Ivanova, E., Portell, A., Lizotte, P. H., Aref, A. R., Eliane, J. P. & Hammond, M. R. & 15 others, Vitzthum, H., Blackmon, S. M., Li, B., Gopalakrishnan, V., Reddy, S. M., Cooper, Z. A., Paweletz, C. P., Barbie, D. A., Stemmer-Rachamimov, A., Flaherty, K. T., Wargo, J. A., Boland, G. M., Sullivan, R. J., Getz, G. & Hacohen, N., 1 Nov 2018, In: Cell. 175, 4, p. 998-1013.e20

      Research output: Contribution to journalArticlepeer-review

      Open Access
    • Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq

      Filbin, M. G., Tirosh, I., Hovestadt, V., Shaw, M. L., Escalante, L. E., Mathewson, N. D., Neftel, C., Frank, N., Pelton, K., Hebert, C. M., Haberler, C., Yizhak, K., Gojo, J., Egervari, K., Mount, C., Van Galen, P., Bonal, D. M., Nguyen, Q. D., Beck, A. & Sinai, C. & 29 others, Czech, T., Dorfer, C., Goumnerova, L., Lavarino, C., Carcaboso, A. M., Mora, J., Mylvaganam, R., Luo, C. C., Peyrl, A., Popović, M., Azizi, A., Batchelor, T. T., Frosch, M. P., Martinez-Lage, M., Kieran, M. W., Bandopadhayay, P., Beroukhim, R., Fritsch, G., Getz, G., Rozenblatt-Rosen, O., Wucherpfennig, K. W., Louis, D. N., Monje, M., Slavc, I., Ligon, K. L., Golub, T. R., Regev, A., Bernstein, B. E. & Suvà, M. L., 20 Apr 2018, In: Science. 360, 6386, p. 331-335 5 p.

      Research output: Contribution to journalArticlepeer-review

      Open Access
    • 2017

      An integrated computational and experimental study uncovers FUT9 as a metabolic driver of colorectal cancer

      Auslander, N., Cunningham, C. E., Toosi, B. M., McEwen, E. J., Yizhak, K., Vizeacoumar, F. S., Parameswaran, S., Gonen, N., Freywald, T., Bhanumathy, K. K., Freywald, A., Vizeacoumar, F. J. & Ruppin, E., Dec 2017, In: Molecular Systems Biology. 13, 12, 956.

      Research output: Contribution to journalArticlepeer-review

      Open Access
    • Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq

      Venteicher, A. S., Tirosh, I., Hebert, C., Yizhak, K., Neftel, C., Filbin, M. G., Hovestadt, V., Escalante, L. E., Shaw, M. L., Rodman, C., Gillespie, S. M., Dionne, D., Luo, C. C., Ravichandran, H., Mylvaganam, R., Mount, C., Onozato, M. L., Nahed, B. V., Wakimoto, H. & Curry, W. T. & 14 others, Iafrate, A. J., Rivera, M. N., Frosch, M. P., Golub, T. R., Brastianos, P. K., Getz, G., Patel, A. P., Monje, M., Cahill, D. P., Rozenblatt-Rosen, O., Louis, D. N., Bernstein, B. E., Regev, A. & Suvà, M. L., 31 Mar 2017, In: Science. 355, 6332, aai8478.

      Research output: Contribution to journalArticlepeer-review

      Open Access
    • Resistance to checkpoint blockade therapy through inactivation of antigen presentation

      Sade-Feldman, M., Jiao, Y. J., Chen, J. H., Rooney, M. S., Barzily-Rokni, M., Eliane, J. P., Bjorgaard, S. L., Hammond, M. R., Vitzthum, H., Blackmon, S. M., Frederick, D. T., Hazar-Rethinam, M., Nadres, B. A., Van Seventer, E. E., Shukla, S. A., Yizhak, K., Ray, J. P., Rosebrock, D., Livitz, D. & Adalsteinsson, V. & 11 others, Getz, G., Duncan, L. M., Li, B., Corcoran, R. B., Lawrence, D. P., Stemmer-Rachamimov, A., Boland, G. M., Landau, D. A., Flaherty, K. T., Sullivan, R. J. & Hacohen, N., 1 Dec 2017, In: Nature Communications. 8, 1, 1136.

      Research output: Contribution to journalArticlepeer-review

      Open Access
    • Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer

      Puram, S. V., Tirosh, I., Parikh, A. S., Patel, A. P., Yizhak, K., Gillespie, S., Rodman, C., Luo, C. L., Mroz, E. A., Emerick, K. S., Deschler, D. G., Varvares, M. A., Mylvaganam, R., Rozenblatt-Rosen, O., Rocco, J. W., Faquin, W. C., Lin, D. T., Regev, A. & Bernstein, B. E., 14 Dec 2017, In: Cell. 171, 7, p. 1611-1624.e24

      Research output: Contribution to journalArticlepeer-review

      Open Access
    • 2016

      A joint analysis of transcriptomic and metabolomic data uncovers enhanced enzyme-metabolite coupling in breast cancer

      Auslander, N., Yizhak, K., Weinstock, A., Budhu, A., Tang, W., Wang, X. W., Ambs, S. & Ruppin, E., 13 Jul 2016, In: Scientific Reports. 6, 29662.

      Research output: Contribution to journalArticlepeer-review

      Open Access
    • Essential genes embody increased mutational robustness to compensate for the lack of backup genetic redundancy

      Cohen, O., Oberhardt, M., Yizhak, K. & Ruppin, E., Dec 2016, In: PLoS ONE. 11, 12, e0168444.

      Research output: Contribution to journalArticlepeer-review

      Open Access
    • Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma

      Tirosh, I., Venteicher, A. S., Hebert, C., Escalante, L. E., Patel, A. P., Yizhak, K., Fisher, J. M., Rodman, C., Mount, C., Filbin, M. G., Neftel, C., Desai, N., Nyman, J., Izar, B., Luo, C. C., Francis, J. M., Patel, A. A., Onozato, M. L., Riggi, N. & Livak, K. J. & 18 others, Gennert, D., Satija, R., Nahed, B. V., Curry, W. T., Martuza, R. L., Mylvaganam, R., Iafrate, A. J., Frosch, M. P., Golub, T. R., Rivera, M. N., Getz, G., Rozenblatt-Rosen, O., Cahill, D. P., Monje, M., Bernstein, B. E., Louis, D. N., Regev, A. & Suvà, M. L., 10 Nov 2016, In: Nature. 539, 7628, p. 309-313 5 p.

      Research output: Contribution to journalArticlepeer-review

      Open Access
    • 2015

      Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis

      Rabinovich, S., Adler, L., Yizhak, K., Sarver, A., Silberman, A., Agron, S., Stettner, N., Sun, Q., Brandis, A., Helbling, D., Korman, S., Itzkovitz, S., Dimmock, D., Ulitsky, I., Nagamani, S. C. S., Ruppin, E. & Erez, A., 19 Nov 2015, In: Nature. 527, 7578, p. 379-383 5 p.

      Research output: Contribution to journalArticlepeer-review

      Open Access
    • 2014

      A computational study of the Warburg effect identifies metabolic targets inhibiting cancer migration

      Yizhak, K., Le Dévédec, S. E., Rogkoti, V. M., Baenke, F., De Boer, V. C., Frezza, C., Schulze, A., Van De Water, B. & Ruppin, E., Aug 2014, In: Molecular Systems Biology. 10, 8, 744.

      Research output: Contribution to journalArticlepeer-review

      Open Access
    • A computational study of the Warburg effect identifies metabolic targets inhibiting cancer migration (vol 10, 744, 2014)

      Yizhak, K., Le Devedec, S. E., Rogkoti, V. M., Baenke, F., de Boer, V. C., Frezza, C., Schulze, A., van de Water, B. & Ruppin, E., Nov 2014, In: Molecular Systems Biology. 10, 11

      Research output: Contribution to journalArticlepeer-review

    • Integrating transcriptomics with metabolic modeling predicts biomarkers and drug targets for Alzheimer's disease

      Stempler, S., Yizhak, K. & Ruppin, E., 15 Aug 2014, In: PLoS ONE. 9, 8, e105383.

      Research output: Contribution to journalArticlepeer-review

      Open Access
    • Maximal sum of metabolic exchange fluxes outperforms biomass yield as a predictor of growth rate of microorganisms

      Zarecki, R., Oberhardt, M. A., Yizhak, K., Wagner, A., Segal, E. S., Freilich, S., Henry, C. S., Gophna, U. & Ruppin, E., 27 May 2014, In: PLoS ONE. 9, 5, e98372.

      Research output: Contribution to journalArticlepeer-review

      Open Access
    • Phenotype-based cell-specific metabolic modeling reveals metabolic liabilities of cancer

      Yizhak, K., Gaude, E., Le Dévédec, S., Waldman, Y. Y., Stein, G. Y., van de Water, B., Frezza, C. & Ruppin, E., 21 Nov 2014, In: eLife. 3, November, p. 1-23 23 p., e03641.

      Research output: Contribution to journalArticlepeer-review

      Open Access
    • 2013

      Model-based identification of drug targets that revert disrupted metabolism and its application to ageing

      Yizhak, K., Gabay, O., Cohen, H. & Ruppin, E., 2013, In: Nature Communications. 4, 2632.

      Research output: Contribution to journalArticlepeer-review

      Open Access
    • p53 promotes the expression of gluconeogenesis-related genes and enhances hepatic glucose production

      Goldstein, I., Yizhak, K., Madar, S., Goldfinger, N., Ruppin, E. & Rotter, V., 2013, In: Cancer & metabolism. 1, 1, 6 p.

      Research output: Contribution to journalArticlepeer-review

    • 2011

      Metabolic modeling of endosymbiont genome reduction on a temporal scale

      Yizhak, K., Tuller, T., Papp, B. & Ruppin, E., 2011, In: Molecular Systems Biology. 7, 479.

      Research output: Contribution to journalArticlepeer-review

      Open Access
    • 2010

      Integrating quantitative proteomics and metabolomics with a genome-scale metabolic network model

      Yizhak, K., Benyamini, T., Liebermeister, W., Ruppin, E. & Shlomi, T., 1 Jun 2010, In: Bioinformatics. 26, 12, p. i255-i260 btq183.

      Research output: Contribution to journalArticlepeer-review

      Open Access