Balancing Nonsense Mutation Readthrough and Toxicity of Designer Aminoglycosides for Treatment of Genetic Diseases

S Guchhait; A Khononov; T Pienko; V Belakhov; T Baasov

doi:10.1021/acsmedchemlett.3c00089

Balancing Nonsense Mutation Readthrough and Toxicity of Designer Aminoglycosides for Treatment of Genetic Diseases

S Guchhait
, A Khononov
, T Pienko
, V Belakhov
, T Baasov

Chemistry

Research output: Contribution to journal › Article › peer-review

Original language	American English
Pages (from-to)	794-801
Number of pages	8
Journal	ACS Medicinal Chemistry Letters
Volume	14
Issue number	6
DOIs	https://doi.org/10.1021/acsmedchemlett.3c00089
State	Published - 27 Apr 2023

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

&nbsp
Aminoglycosides
Cystic fibrosis
Genetic diseases
Nonsense mutations
Translational readthrough

Access to Document

10.1021/acsmedchemlett.3c00089

Cite this

@article{d26485fa8b4a4dbf8d431bb0a130fc98,

title = "Balancing Nonsense Mutation Readthrough and Toxicity of Designer Aminoglycosides for Treatment of Genetic Diseases",

keywords = "\&nbsp, Aminoglycosides, Cystic fibrosis, Genetic diseases, Nonsense mutations, Translational readthrough",

author = "S Guchhait and A Khononov and T Pienko and V Belakhov and T Baasov",

year = "2023",

month = apr,

day = "27",

doi = "10.1021/acsmedchemlett.3c00089",

language = "American English",

volume = "14",

pages = "794--801",

number = "6",

}

TY - JOUR

T1 - Balancing Nonsense Mutation Readthrough and Toxicity of Designer Aminoglycosides for Treatment of Genetic Diseases

AU - Guchhait, S

AU - Khononov, A

AU - Pienko, T

AU - Belakhov, V

AU - Baasov, T

PY - 2023/4/27

Y1 - 2023/4/27

KW - &nbsp

KW - Aminoglycosides

KW - Cystic fibrosis

KW - Genetic diseases

KW - Nonsense mutations

KW - Translational readthrough

UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=technion_pure2wos&SrcAuth=WosAPI&KeyUT=WOS:000981921400001&DestLinkType=FullRecord&DestApp=WOS

U2 - 10.1021/acsmedchemlett.3c00089

DO - 10.1021/acsmedchemlett.3c00089

M3 - Article

C2 - 37312846

VL - 14

SP - 794

EP - 801

JO - ACS Medicinal Chemistry Letters

JF - ACS Medicinal Chemistry Letters

IS - 6

ER -

Balancing Nonsense Mutation Readthrough and Toxicity of Designer Aminoglycosides for Treatment of Genetic Diseases

UN SDGs

Keywords

Access to Document

Other files and links

Cite this