Breast cancer polygenic risk scores derived in White European populations are not calibrated for women of Ashkenazi Jewish descent: Breast cancer polygenic risk scores derived in White European populations are not calibrated for women of Ashkenazi Jewish descent (Genetics in Medicine (2023) 25(9), (S1098360023008596), (10.1016/j.gim.2023.100846))

Correction to: Genetics in Medicine 2023; https://doi.org/10.1016/j.gim.2023.100846, published online 12 April 2023. In the article “Breast cancer polygenic risk scores derived in White European populations are not calibrated for women of Ashkenazi Jewish descent” (Genet Med 2023;25:100846), the following updates were made. On page 4 (left-hand column, first paragraph), “2 risk alleles = p2 = 0.242 = 0.058, 1 risk allele = 2pq = 2(0.24 × 0.76) = 0.36 and 0 risk alleles = q2 = 0.762 = 0.58. The population risk for the nonrisk allele genotype q2 is (0.058 × 1.242) + (0.36 × 1.24) + (0.58 × 1) = 1.12. The risk for each genotype is homozygous risk allele (p2) = 1.242/1.12 = 1.37, heterozygous risk allele (2pq) = 1.24/1.12 = 1.11, homozygous nonrisk allele (q2) = 1/1.12 = 0.89.^17,18” was changed to “Population frequencies are as follows: 2 risk alleles = p² = 0.24² = 0.058, 1 risk allele = 2pq = 2(0.24 × 0.76) = 0.36 and 0 risk alleles = q² = 0.76² = 0.58. The population risk for the nonrisk allele genotype q² is (0.058 × 1.24²) + (0.36 × 1.24) + (0.58 × 1) = 1.12. The risk for each genotype is homozygous risk allele (p²) = 1.24²/1.12 = 1.37, heterozygous risk allele (2pq) = 1.24/1.12 = 1.11, homozygous nonrisk allele (q²) = 1/1.12 = 0.89.^17,18” On page 7 (Funding section), the following sentence has been added “This work was also funded by Cancer Research UK ACED International Alliance for Cancer Early Detection C19941/A27859.” The authors would like to apologize for any inconvenience this may have caused. The article has been corrected online and can be accessed at https://doi.org/10.1016/j.gim.2023.100846.