Combined tumor and immune signals from genomes or transcriptomes predict outcomes of checkpoint inhibition in melanoma

Keyphrases

• Transcriptome 100%
• Tumor 100%
• Melanoma 100%
• Outcome Prediction 100%
• Checkpoint Inhibition 100%
• Combined Tumor 100%
• Checkpoint Blockade 40%
• Lymphocytes 20%
• Tumor mutational Burden 20%
• T Cells 20%
• Improved Outcomes 20%
• Response Model 20%
• Cell-to-cell 20%
• B Cells 20%
• Survival Prediction 20%
• Gene Pairs 20%
• RNA-based 20%
• Expressed Genes 20%
• Intrinsic Features 20%
• Model Combining 20%
• Whole Exome 20%
• Integrative Model 20%
• TBX3 20%
• Bulk RNA-seq 20%
• Underexploited 20%
• Melanoma Outcomes 20%
• MAP4K4 20%
• Cellular Burden 20%
• DNA Bases 20%
• Immune Checkpoint Blockade 20%
• Tumor-infiltrating T Cells 20%

Immunology and Microbiology

• Transcriptome 100%
• T Cell 100%
• B Cell 50%
• Immune Checkpoint Blockade 50%
• T Cell Receptor 50%
• Intravenous Immunoglobulin 50%
• DNA RNA Hybridization 50%
• RNA Sequence 50%
• Survival Prediction 50%
• Exome 50%
• Lymphocyte 50%
• Ribonucleic Acid 50%
• Tumor Mutational Burden 50%

Biochemistry, Genetics and Molecular Biology

• T Cell 100%
• Transcriptome 100%
• Immune Checkpoints 50%
• RNA 50%
• Exome 50%
• T Cell Receptor 50%
• DNA RNA Hybridization 50%
• Survival Prediction 50%
• TBX3 50%
• B Cell 50%
• Intravenous Immunoglobulin 50%
• Lymphocyte 50%
• Bulk RNA Sequencing 50%