TY - JOUR
T1 - Continuous fluid resuscitation and splenectomy for treatment of uncontrolled hemorrhagic shock after massive splenic injury
AU - Hatoum, Ossama Abu
AU - Bashenko, Yulia
AU - Hirsh, Mark
AU - Krausz, Michael M.
PY - 2002/2
Y1 - 2002/2
N2 - Using a standardized massive splenic injury (MSI) model of uncontrolled hemorrhagic shock, we studied the effect of continuous fluid resuscitation and splenectomy on the hemodynamic response and survival in rats. The animals were randomized into seven groups: group 1 (n = 8), sham-operated; group 2 (n = 8), MSI untreated; group 3 (n = 8), MSI treated with 7.5 mL/kg/h of 7.5% NaCl (hypertonic saline [HTS]) for 1 hour; group 4 (n = 8), MSI treated with 7.5 mL/kg/h hydroxyethyl starch (HES-7.5) for 1 hour; group 5 (n = 8) MSI treated with 35 mL/kg/h Ringer’s lactate (RL) solution (RL-35) for 1 hour; group 6 (n = 8) MSI treated with 70 mL/kg/h RL for 1 hour (RL-70); and group 7 (n = 8), MSI treated with 105 mL/kg/h RL for 1 hour (RL-105). In all MSI groups, splenectomy was performed 45 minutes after injury. MSI in untreated group 2 resulted in a fall of mean arterial pressure from 105.9 ± 10.7 mm Hg to 27.0 ± 6.7 mm Hg (p < 0.001) in 60 minutes. Mean survival time after splenectomy in this group was 160.7 ± 29.7 minutes, and total blood loss was 34.8 ± 4.7% of blood volume. Continuous HTS infusion with splenectomy in group 3 was followed by a total blood loss of 38.7 ± 4.4% and mean survival time was 176.5 ± 23.2 minutes. HES-7.5 infusion and splenectomy was followed by a total blood loss of 39.6 ± 2.5% and survival time was 171.6 ± 19.5 minutes. Continuous infusion of increasing volumes of RL in groups 5, 6, and 7 was followed by increase in blood loss to 29.0 ± 4.1%, 50.2 ± 3.1% (p < 0.001), and 62.7 ± 7.1% (p < 0.002) of total blood volume, respectively. Mean survival time in groups 5, 6, and 7 was 233.5 ± 6.5 minutes (p < 0.04), 207.6 ± 17.0 minutes (p < 0.05), and 158 ± 26 minutes, respectively. Continuous infusion of large-volume RL and splenectomy after massive splenic injury resulted in a significant increase in intra-abdominal bleeding and shortened survival time compared with small-volume RL infusion.
AB - Using a standardized massive splenic injury (MSI) model of uncontrolled hemorrhagic shock, we studied the effect of continuous fluid resuscitation and splenectomy on the hemodynamic response and survival in rats. The animals were randomized into seven groups: group 1 (n = 8), sham-operated; group 2 (n = 8), MSI untreated; group 3 (n = 8), MSI treated with 7.5 mL/kg/h of 7.5% NaCl (hypertonic saline [HTS]) for 1 hour; group 4 (n = 8), MSI treated with 7.5 mL/kg/h hydroxyethyl starch (HES-7.5) for 1 hour; group 5 (n = 8) MSI treated with 35 mL/kg/h Ringer’s lactate (RL) solution (RL-35) for 1 hour; group 6 (n = 8) MSI treated with 70 mL/kg/h RL for 1 hour (RL-70); and group 7 (n = 8), MSI treated with 105 mL/kg/h RL for 1 hour (RL-105). In all MSI groups, splenectomy was performed 45 minutes after injury. MSI in untreated group 2 resulted in a fall of mean arterial pressure from 105.9 ± 10.7 mm Hg to 27.0 ± 6.7 mm Hg (p < 0.001) in 60 minutes. Mean survival time after splenectomy in this group was 160.7 ± 29.7 minutes, and total blood loss was 34.8 ± 4.7% of blood volume. Continuous HTS infusion with splenectomy in group 3 was followed by a total blood loss of 38.7 ± 4.4% and mean survival time was 176.5 ± 23.2 minutes. HES-7.5 infusion and splenectomy was followed by a total blood loss of 39.6 ± 2.5% and survival time was 171.6 ± 19.5 minutes. Continuous infusion of increasing volumes of RL in groups 5, 6, and 7 was followed by increase in blood loss to 29.0 ± 4.1%, 50.2 ± 3.1% (p < 0.001), and 62.7 ± 7.1% (p < 0.002) of total blood volume, respectively. Mean survival time in groups 5, 6, and 7 was 233.5 ± 6.5 minutes (p < 0.04), 207.6 ± 17.0 minutes (p < 0.05), and 158 ± 26 minutes, respectively. Continuous infusion of large-volume RL and splenectomy after massive splenic injury resulted in a significant increase in intra-abdominal bleeding and shortened survival time compared with small-volume RL infusion.
KW - Hydroxyethyl starch
KW - Hypertonic saline
KW - Ringer’s lactate
KW - Splenectomy
KW - Splenic injury
KW - Uncontrolled hemorrhage
UR - http://www.scopus.com/inward/record.url?scp=0036188557&partnerID=8YFLogxK
U2 - 10.1097/00005373-200202000-00009
DO - 10.1097/00005373-200202000-00009
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AN - SCOPUS:0036188557
SN - 0022-5282
VL - 52
SP - 253
EP - 258
JO - Journal of Trauma
JF - Journal of Trauma
IS - 2
ER -