TY - JOUR
T1 - Design Optimization and Performance Studies of an Adult Scale Viscous Impeller Pump for Powered Fontan in an Idealized Total Cavopulmonary Connection
AU - Kennington, Jeffrey R.
AU - Frankel, Steven H.
AU - Chen, Jun
AU - Koenig, Steven C.
AU - Sobieski, Michael A.
AU - Giridharan, Guruprasad A.
AU - Rodefeld, Mark D.
N1 - Funding Information:
We gratefully acknowledge partial financial support from the Indiana Clinical and Translational Sciences Institute, Indiana University and Purdue University. This work was also supported in part by National Institutes of Health grants HL080089 and HL098353.
PY - 2011/12
Y1 - 2011/12
N2 - Numerical and experimental studies are carried out to assess the hydraulic and hemodynamic performance and the biocompatibility of a viscous impeller pump (VIP) for cavopulmonary assist in patients with a univentricular Fontan circulation. Computational fluid dynamics (CFD) predictions of impeller performance are shown to be in very good agreement with measured pressure-flow data obtained in a Fontan mock-circulation system. Additional CFD and experimental design studies intending to balance pump performance and biocompatibility with the manufacturability limitations of a percutaneous expandable impeller are also reported. The numerical models and experimental studies confirm excellent performance of the VIP with augmentation of Fontan pressure up to 35 mmHg for flow rates up to 4. 5 L/min and operational speeds no higher than 5000 RPM. Scalar stress predictions on the VIP surface and laboratory hemolysis measurements both demonstrate very low hemolysis potential. The impeller designs reported offer ideal performance and can meet manufacturing tolerances of a flexible, catheter-based percutaneous expandable rotary pump.
AB - Numerical and experimental studies are carried out to assess the hydraulic and hemodynamic performance and the biocompatibility of a viscous impeller pump (VIP) for cavopulmonary assist in patients with a univentricular Fontan circulation. Computational fluid dynamics (CFD) predictions of impeller performance are shown to be in very good agreement with measured pressure-flow data obtained in a Fontan mock-circulation system. Additional CFD and experimental design studies intending to balance pump performance and biocompatibility with the manufacturability limitations of a percutaneous expandable impeller are also reported. The numerical models and experimental studies confirm excellent performance of the VIP with augmentation of Fontan pressure up to 35 mmHg for flow rates up to 4. 5 L/min and operational speeds no higher than 5000 RPM. Scalar stress predictions on the VIP surface and laboratory hemolysis measurements both demonstrate very low hemolysis potential. The impeller designs reported offer ideal performance and can meet manufacturing tolerances of a flexible, catheter-based percutaneous expandable rotary pump.
KW - Assist device
KW - Hemolysis
KW - Hypoplastic
KW - Powered Fontan
KW - Total cavopulmonary connection
UR - http://www.scopus.com/inward/record.url?scp=82955193282&partnerID=8YFLogxK
U2 - 10.1007/s13239-011-0058-2
DO - 10.1007/s13239-011-0058-2
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AN - SCOPUS:82955193282
SN - 1869-408X
VL - 2
SP - 237
EP - 243
JO - Cardiovascular Engineering and Technology
JF - Cardiovascular Engineering and Technology
IS - 4
ER -