TY - JOUR
T1 - Emerging implications for ribosomes in proximity to mitochondria
AU - Cohen, Bar
AU - Golani-Armon, Adi
AU - Arava, Yoav S.
N1 - Publisher Copyright:
© 2023 Elsevier Ltd
PY - 2024/2/15
Y1 - 2024/2/15
N2 - Synthesis of all proteins in eukaryotic cells, apart from a few organellar proteins, is done by cytosolic ribosomes. Many of these ribosomes are localized in the vicinity of the functional site of their encoded protein, enabling local protein synthesis. Studies in various organisms and tissues revealed that such locally translating ribosomes are also present near mitochondria. Here, we provide a brief summary of evidence for localized translation near mitochondria, then present data suggesting that these localized ribosomes may enable local translational regulatory processes in response to mitochondria needs. Finally, we describe the involvement of such localized ribosomes in the quality control of protein synthesis and mitochondria. These emerging views suggest that ribosomes localized near mitochondria are a hub for a variety of activities with diverse implications on mitochondria physiology.
AB - Synthesis of all proteins in eukaryotic cells, apart from a few organellar proteins, is done by cytosolic ribosomes. Many of these ribosomes are localized in the vicinity of the functional site of their encoded protein, enabling local protein synthesis. Studies in various organisms and tissues revealed that such locally translating ribosomes are also present near mitochondria. Here, we provide a brief summary of evidence for localized translation near mitochondria, then present data suggesting that these localized ribosomes may enable local translational regulatory processes in response to mitochondria needs. Finally, we describe the involvement of such localized ribosomes in the quality control of protein synthesis and mitochondria. These emerging views suggest that ribosomes localized near mitochondria are a hub for a variety of activities with diverse implications on mitochondria physiology.
KW - Localized translation
KW - MitoRQC
KW - Mitochondria
KW - RNA binding proteins
KW - Ribosomal quality control
KW - Ribosomes
KW - Translation regulation
KW - mRNA localization
UR - http://www.scopus.com/inward/record.url?scp=85146478914&partnerID=8YFLogxK
U2 - 10.1016/j.semcdb.2023.01.003
DO - 10.1016/j.semcdb.2023.01.003
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.systematicreview???
AN - SCOPUS:85146478914
SN - 1084-9521
VL - 154
SP - 123
EP - 130
JO - Seminars in Cell and Developmental Biology
JF - Seminars in Cell and Developmental Biology
ER -