Eyes open on stem cells

Anna Altshuler; Aya Amitai-Lange; Waseem Nasser; Shalini Dimri; Swarnabh Bhattacharya; Beatrice Tiosano; Ramez Barbara; Daniel Aberdam; Shigeto Shimmura; Ruby Shalom-Feuerstein

doi:10.1016/j.stemcr.2023.10.023

Eyes open on stem cells

Anna Altshuler, Aya Amitai-Lange, Waseem Nasser, Shalini Dimri, Swarnabh Bhattacharya, Beatrice Tiosano, Ramez Barbara, Daniel Aberdam, Shigeto Shimmura, Ruby Shalom-Feuerstein

Research output: Contribution to journal › Review article › peer-review

Abstract

Recently, the murine cornea has reemerged as a robust stem cell (SC) model, allowing individual SC tracing in living animals. The cornea has pioneered seminal discoveries in SC biology and regenerative medicine, from the first corneal transplantation in 1905 to the identification of limbal SCs and their transplantation to successfully restore vision in the early 1990s. Recent experiments have exposed unexpected properties attributed to SCs and progenitors and revealed flexibility in the differentiation program and a key role for the SC niche. Here, we discuss the limbal SC model and its broader relevance to other tissues, disease, and therapy.

Original language	English
Pages (from-to)	2313-2327
Number of pages	15
Journal	Stem Cell Reports
Volume	18
Issue number	12
DOIs	https://doi.org/10.1016/j.stemcr.2023.10.023
State	Published - 12 Dec 2023

Keywords

Mice
Animals
Epithelium, Corneal
Limbus Corneae
Cornea
Stem Cells
Cell Differentiation
Stem Cell Transplantation

ASJC Scopus subject areas

Biochemistry
Genetics
Developmental Biology
Cell Biology

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10.1016/j.stemcr.2023.10.023

Cite this

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title = "Eyes open on stem cells",

abstract = "Recently, the murine cornea has reemerged as a robust stem cell (SC) model, allowing individual SC tracing in living animals. The cornea has pioneered seminal discoveries in SC biology and regenerative medicine, from the first corneal transplantation in 1905 to the identification of limbal SCs and their transplantation to successfully restore vision in the early 1990s. Recent experiments have exposed unexpected properties attributed to SCs and progenitors and revealed flexibility in the differentiation program and a key role for the SC niche. Here, we discuss the limbal SC model and its broader relevance to other tissues, disease, and therapy.",

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AU - Altshuler, Anna

AU - Amitai-Lange, Aya

AU - Nasser, Waseem

AU - Dimri, Shalini

AU - Bhattacharya, Swarnabh

AU - Tiosano, Beatrice

AU - Barbara, Ramez

AU - Aberdam, Daniel

AU - Shimmura, Shigeto

AU - Shalom-Feuerstein, Ruby

PY - 2023/12/12

Y1 - 2023/12/12

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AB - Recently, the murine cornea has reemerged as a robust stem cell (SC) model, allowing individual SC tracing in living animals. The cornea has pioneered seminal discoveries in SC biology and regenerative medicine, from the first corneal transplantation in 1905 to the identification of limbal SCs and their transplantation to successfully restore vision in the early 1990s. Recent experiments have exposed unexpected properties attributed to SCs and progenitors and revealed flexibility in the differentiation program and a key role for the SC niche. Here, we discuss the limbal SC model and its broader relevance to other tissues, disease, and therapy.

KW - Mice

KW - Animals

KW - Epithelium, Corneal

KW - Limbus Corneae

KW - Cornea

KW - Stem Cells

KW - Cell Differentiation

KW - Stem Cell Transplantation

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Eyes open on stem cells

Abstract

Keywords

ASJC Scopus subject areas

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