Forging a proteasome α-ring with dedicated proteasome chaperones

Rina Rosenzweig, Michael Glickman

Research output: Contribution to journalShort surveypeer-review

8 Scopus citations

Abstract

Assembly of the 34-subunit, 2.5 megadalton 26S proteasome starts with formation of the seven-membered α-ring. A set of newly identified proteasome chaperones serves as a clamp to seal α-rings with the correct composition. By regulating the efficiency and outcome of this crucial step in proteasome biogenesis, these dedicated proteasome chaperones apparently partake in the stress response and in adaptation to intracellular proteolysis needs.

Original languageEnglish
Pages (from-to)218-220
Number of pages3
JournalNature Structural and Molecular Biology
Volume15
Issue number3
DOIs
StatePublished - Mar 2008

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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