Abstract
The International Society for Clinical Electrophysiology of Vision (ISCEV) standard for full-field electroretinography (ERG) describes a minimum procedure for testing generalized retinal function but encourages more extensive testing. This extended protocol describes a method of assessing the function of the short-wavelength-sensitive cone (S-cone) retinal pathway, using a short-wavelength flash superimposed on a background that saturates the rods and adapts the L/M-cones to elicit a response, known as the S-cone ERG. Stimulus parameters such as the strength and luminance of the flash and background, respectively, and their spectral and temporal characteristics are specified. As a complement to the ISCEV standard, testing the S-cone ERG enables further characterization of light-adapted retinal function and may refine diagnosis of some retinal disorders. Typical applications are described including use in the diagnosis of rod monochromacy and S-cone monochromacy, identification and investigation of cone On-bipolar cell dysfunction and use of the technique to confirm the diagnosis of enhanced S-cone syndrome.
| Original language | English |
|---|---|
| Pages (from-to) | 95-101 |
| Number of pages | 7 |
| Journal | Documenta Ophthalmologica |
| Volume | 140 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1 Apr 2020 |
Keywords
- Clinical standards
- Electroretinogram (ERG)
- Full-field ERG
- International Society for Clinical Electrophysiology of Vision (ISCEV)
- Retinal dystrophy
- Retinopathy
- S-cone ERG
- Short-wavelength-sensitive cone ERG
ASJC Scopus subject areas
- Ophthalmology
- Sensory Systems
- Physiology (medical)