TY - JOUR
T1 - Magnetic resonance-guided focused ultrasound surgery using an enhanced sonication technique in a pig muscle model
AU - Kopelman, Doron
AU - Inbar, Yael
AU - Hanannel, Arik
AU - Freundlich, David
AU - Vitek, Shuki
AU - Schmidt, Rita
AU - Sokolov, Amit
AU - Hatoum, Ossama A.
AU - Rabinovici, Jaron
N1 - Funding Information:
This research was partially funded by a grant from InSightec Ltd., Tirat Hacarmel, Israel.
PY - 2006/8
Y1 - 2006/8
N2 - The purpose of this study: To evaluate the safety and efficacy of an enhanced magnetic resonance-guided focused ultrasound (MRgFUS) emission protocol that results in more extensive treatment by increasing the volume of each focal ablation using the same energy. Materials and methods: Six pigs were treated with an MRgFUS system combined with real-time MR, for imaging and temperature mapping, with 102 "enhanced" and 97 "regular" focal ablations performed on both buttock muscles. Real-time imaging, temperature mapping, and acoustic reflected spectrum data enabled immediate evaluation of the results. MR contrast-enhanced images and pathology examinations were used for confirmation. Results: The location of the ablated volume by "enhanced" sonication is predictable, with a maximum possible shift of 6 mm toward, and 3 mm away, from the transducer. The ablated volume after enhanced sonication was, on average, 1.8 times larger than after a regular sonication of the same energy. Pathology results showed the same thermally induced damage patterns in the enhanced sonications and the regular sonications. Conclusion: Accelerated MRgFUS with enhanced sonication is a safe, controllable, and more effective tissue ablative modality than standard sonication. This new technology may significantly reduce the length of tumor ablation procedures. (Isn't the new technology you're talking about MRgFUS? If so, you don't need to repeat it at the end of this sentence.).
AB - The purpose of this study: To evaluate the safety and efficacy of an enhanced magnetic resonance-guided focused ultrasound (MRgFUS) emission protocol that results in more extensive treatment by increasing the volume of each focal ablation using the same energy. Materials and methods: Six pigs were treated with an MRgFUS system combined with real-time MR, for imaging and temperature mapping, with 102 "enhanced" and 97 "regular" focal ablations performed on both buttock muscles. Real-time imaging, temperature mapping, and acoustic reflected spectrum data enabled immediate evaluation of the results. MR contrast-enhanced images and pathology examinations were used for confirmation. Results: The location of the ablated volume by "enhanced" sonication is predictable, with a maximum possible shift of 6 mm toward, and 3 mm away, from the transducer. The ablated volume after enhanced sonication was, on average, 1.8 times larger than after a regular sonication of the same energy. Pathology results showed the same thermally induced damage patterns in the enhanced sonications and the regular sonications. Conclusion: Accelerated MRgFUS with enhanced sonication is a safe, controllable, and more effective tissue ablative modality than standard sonication. This new technology may significantly reduce the length of tumor ablation procedures. (Isn't the new technology you're talking about MRgFUS? If so, you don't need to repeat it at the end of this sentence.).
KW - Animal experiments
KW - Magnetic resonance-guided focused ultrasound
UR - http://www.scopus.com/inward/record.url?scp=33746185698&partnerID=8YFLogxK
U2 - 10.1016/j.ejrad.2006.04.018
DO - 10.1016/j.ejrad.2006.04.018
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AN - SCOPUS:33746185698
SN - 0720-048X
VL - 59
SP - 190
EP - 197
JO - European Journal of Radiology
JF - European Journal of Radiology
IS - 2
ER -