p53 promotes the expression of gluconeogenesis-related genes and enhances hepatic glucose production

Ido Goldstein; Keren Yizhak; Shalom Madar; Naomi Goldfinger; Eytan Ruppin; Varda Rotter

doi:10.1186/2049-3002-1-9

p53 promotes the expression of gluconeogenesis-related genes and enhances hepatic glucose production

Ido Goldstein, Keren Yizhak, Shalom Madar, Naomi Goldfinger, Eytan Ruppin, Varda Rotter

Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

The p53 tumor suppressor protein is a transcription factor that initiates transcriptional programs aimed at inhibiting carcinogenesis. p53 represses metabolic pathways that support tumor development (such as glycolysis and the pentose phosphate pathway (PPP)) and enhances metabolic pathways that are considered counter-tumorigenic such as fatty acid oxidation.

Original language	American English
Number of pages	6
Journal	Cancer & metabolism
Volume	1
Issue number	1
DOIs	https://doi.org/10.1186/2049-3002-1-9
State	Published - 2013

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title = "p53 promotes the expression of gluconeogenesis-related genes and enhances hepatic glucose production",

abstract = "The p53 tumor suppressor protein is a transcription factor that initiates transcriptional programs aimed at inhibiting carcinogenesis. p53 represses metabolic pathways that support tumor development (such as glycolysis and the pentose phosphate pathway (PPP)) and enhances metabolic pathways that are considered counter-tumorigenic such as fatty acid oxidation.",

author = "Ido Goldstein and Keren Yizhak and Shalom Madar and Naomi Goldfinger and Eytan Ruppin and Varda Rotter",

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doi = "10.1186/2049-3002-1-9",

language = "American English",

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T1 - p53 promotes the expression of gluconeogenesis-related genes and enhances hepatic glucose production

AU - Goldstein, Ido

AU - Yizhak, Keren

AU - Madar, Shalom

AU - Goldfinger, Naomi

AU - Ruppin, Eytan

AU - Rotter, Varda

PY - 2013

Y1 - 2013

N2 - The p53 tumor suppressor protein is a transcription factor that initiates transcriptional programs aimed at inhibiting carcinogenesis. p53 represses metabolic pathways that support tumor development (such as glycolysis and the pentose phosphate pathway (PPP)) and enhances metabolic pathways that are considered counter-tumorigenic such as fatty acid oxidation.

AB - The p53 tumor suppressor protein is a transcription factor that initiates transcriptional programs aimed at inhibiting carcinogenesis. p53 represses metabolic pathways that support tumor development (such as glycolysis and the pentose phosphate pathway (PPP)) and enhances metabolic pathways that are considered counter-tumorigenic such as fatty acid oxidation.

U2 - 10.1186/2049-3002-1-9

DO - 10.1186/2049-3002-1-9

M3 - Article

SN - 2049-3002

VL - 1

JO - Cancer & metabolism

JF - Cancer & metabolism

IS - 1

ER -

p53 promotes the expression of gluconeogenesis-related genes and enhances hepatic glucose production

Abstract

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