PCI Complexes: Beyond the Proteasome, CSN, and eIF3 Troika

Elah Pick, Kay Hofmann, Michael Glickman

Research output: Contribution to journalShort surveypeer-review

98 Scopus citations

Abstract

The bipartite PCI domain serves as the principal scaffold for proteasome lid, CSN, and eIF3, complexes that influence protein life span. PCI domains are also found in newly identified complexes directing nucleic acid regulation. The breadth of functions associated with the extended PCI family is a factor of shared subunits, among them a common factor Sem1/DSS1 that facilitates complex assembly.

Original languageEnglish
Pages (from-to)260-264
Number of pages5
JournalMolecular Cell
Volume35
Issue number3
DOIs
StatePublished - 14 Aug 2009

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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