Abstract
The low solubility in biological fluids displayed by about 50% of the drugs still remains the main limitation in oral, parenteral, and transdermal administration. Among the existing strategies to overcome these drawbacks, inclusion of hydrophobic drugs into polymeric micelles is one of the most attractive alternatives. Amphiphilic poly(ethylene oxide)-poly(propylene oxide) block copolymers are thermoresponsive materials that display unique aggregation properties in aqueous medium. Due to their ability to form stable micellar systems in water, these materials are broadly studied as hydrosolubilizers for poorly water-soluble drugs. The present review provides a concise description of the most important applications of PEO-PPO-based copolymers in the Pharmaceutical Technology field as means for attaining improved solubility, stability, release, and bioavailability of drugs.
| Original language | English |
|---|---|
| Pages (from-to) | 303-317 |
| Number of pages | 15 |
| Journal | European Journal of Pharmaceutics and Biopharmaceutics |
| Volume | 66 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jun 2007 |
| Externally published | Yes |
Keywords
- Bioavailability
- Drug delivery
- Drug solubilization
- Drug stability
- Poloxamer
- Poloxamine
- Poly(ethylene oxide)-poly(propylene oxide) block copolymers
ASJC Scopus subject areas
- Biotechnology
- Pharmaceutical Science