TY - JOUR
T1 - Renal functional recovery among inpatients
T2 - A plausible marker of reduced renal functional reserve
AU - Gorelik, Yuri
AU - Khamaisi, Mogher
AU - Abassi, Zaid
AU - Evans, Roger G.
AU - Heyman, Samuel N.
N1 - Publisher Copyright:
© 2021 John Wiley & Sons Australia, Ltd
PY - 2021/12
Y1 - 2021/12
N2 - Renal functional reserve (RFR) reflects the ability of the kidney to enhance glomerular filtration rate (GFR) in response to a protein load. Chronic kidney disease (CKD) leads to diminished RFR, since the capacity for whole-body GFR to increase through hyperfiltration of remaining nephrons is limited. Evaluating 41,456 inpatients following computerised tomography we reported many exhibiting acute kidney injury (AKI) but more patients with recovering kidney function (AKR), presumably reflecting resolution of their critical conditions. The incidences of AKI and AKR were closely co-associated and were both inversely correlated with baseline kidney function. We discuss this phenomenon, arguing that AKR among inpatients with an acute illness, like AKI, may often reflect underlying subtle CKD with diminished RFR.
AB - Renal functional reserve (RFR) reflects the ability of the kidney to enhance glomerular filtration rate (GFR) in response to a protein load. Chronic kidney disease (CKD) leads to diminished RFR, since the capacity for whole-body GFR to increase through hyperfiltration of remaining nephrons is limited. Evaluating 41,456 inpatients following computerised tomography we reported many exhibiting acute kidney injury (AKI) but more patients with recovering kidney function (AKR), presumably reflecting resolution of their critical conditions. The incidences of AKI and AKR were closely co-associated and were both inversely correlated with baseline kidney function. We discuss this phenomenon, arguing that AKR among inpatients with an acute illness, like AKI, may often reflect underlying subtle CKD with diminished RFR.
KW - acute kidney failure
KW - clinical study
KW - glomerular filtration rate
KW - renal functional reserve
UR - http://www.scopus.com/inward/record.url?scp=85115133416&partnerID=8YFLogxK
U2 - 10.1111/1440-1681.13545
DO - 10.1111/1440-1681.13545
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AN - SCOPUS:85115133416
SN - 0305-1870
VL - 48
SP - 1724
EP - 1727
JO - Clinical and Experimental Pharmacology and Physiology
JF - Clinical and Experimental Pharmacology and Physiology
IS - 12
ER -
