The Tishchenko reaction mediated by organo-f-complexes: the myths and obstacles

Aditya L. Shinde, Moris S. Eisen, Tapas Ghatak

Research output: Contribution to journalReview articlepeer-review


For over a century, the Tishchenko reaction has been a valuable technique for synthesizing esters from aldehydes, serving a variety of applications in different domains. Beyond the remarkable advances in organoactinide and organolanthanide chemistry over the past two decades, there has been a significant increase in the research of the electrophilic d0/fn chemistry of organoactinide and organolanthanide compounds due to the captivating interplay between their structure and reactivity, and their exceptional performance in various homogeneous catalytic processes. The remarkable influence of ligand design, both in terms of steric hindrance and electronic properties, on the catalytic activity of organo-f-element complexes in organic transformations is well-established. However, the traditional view was that the significant oxophilicity of actinide and lanthanide complexes makes them unfavorable for reactions involving oxygen because of catalytic poisoning and their applications have been relatively limited, primarily focused on hydroalkoxylation, small-molecule activation, and cyclic ester polymerization. This review dissects the intricate interplay between ligand design and catalytic activity in actinide and lanthanide complexes, specifically in the context of the Tishchenko esterification.

Original languageEnglish
Pages (from-to)17901-17928
Number of pages28
JournalRSC Advances
Issue number25
StatePublished - 5 Jun 2024

ASJC Scopus subject areas

  • General Chemistry
  • General Chemical Engineering


Dive into the research topics of 'The Tishchenko reaction mediated by organo-f-complexes: the myths and obstacles'. Together they form a unique fingerprint.

Cite this