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Tofacitinib Regulates Endostatin via Effects on CD147 and Cathepsin S
Devy Zisman
, Hala Sabtan
, Maya M. Rahat
, Elina Simanovich
, Amir Haddad
, Tal Gazitt
, Joy Feld
, Gleb Slobodin
, Adi Kibari
, Muna Elias
, Michal A. Rahat
Medicine
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Keyphrases
CD147
100%
Endostatin
100%
Cathepsin S
100%
Tofacitinib
100%
Through Effect
100%
Angiogenesis
33%
20S Proteasome
33%
Rheumatoid Arthritis
22%
Angiogenic Factors
22%
Matrix metalloproteinase-9 (MMP-9)
22%
Recombinant
11%
Fibroblasts
11%
Collagen
11%
Disease Severity
11%
Serum Samples
11%
Antiangiogenic Factors
11%
Rheumatoid Arthritis Patients
11%
Dual Effect
11%
Small Interfering RNA (siRNA)
11%
Monocytic
11%
U937 Cells
11%
HT1080
11%
Angiogenic Potential
11%
STAT3 Phosphorylation
11%
Rheumatoid Arthritis Treatment
11%
MiR-146a-5p
11%
JAK3 Inhibitor
11%
Level Matrix
11%
Pharmacology, Toxicology and Pharmaceutical Science
Cathepsin S
100%
Endostatin
100%
Tofacitinib
100%
Rheumatoid Arthritis
44%
Inflammatory Arthritis
44%
Angiogenic Factor
33%
Proteasome
33%
Gelatinase B
22%
Antiangiogenic
11%
Disease Severity
11%
Small Interfering RNA
11%
microRNA 146a
11%
Matrix Metalloproteinase
11%
Messenger RNA
11%
Biochemistry, Genetics and Molecular Biology
Cathepsin S
100%
Tofacitinib
100%
Endostatin
100%
Angiogenesis
33%
Proteasome
33%
Gelatinase B
22%
MMP9
22%
Small Interfering RNA
11%
Coculture
11%
STAT3
11%
Matrix Metalloproteinase
11%
Messenger RNA
11%
Fibroblast
11%
Immunology and Microbiology
Endostatin
100%
Tofacitinib
100%
Inflammatory Arthritis
44%
Angiogenic Factor
33%
Angiogenesis
33%
Proteasome
33%
Coculture
11%
Cell Line
11%
STAT3
11%
Immunology
11%
Fibroblast
11%