Viral vectors and delivery systems for gene therapy in cardiovascular medicine - The intersection of molecular biology and interventional cardiology

MY Flugelman; DA Halon; BS Lewis; P Touboul

Viral vectors and delivery systems for gene therapy in cardiovascular medicine - The intersection of molecular biology and interventional cardiology

MY Flugelman, DA Halon, BS Lewis, P Touboul (Editor)

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

A significant number of patients with syndromes related to arterial obstructive disease cannot benefit from current therapeutic modalities. Theoretically, gene transfer can be used in these and most other patients with cardiovascular disorders. With the completion of the human gene project it can be anticipated that genes relevant to cardiovascular medicine will be identified in the near future. The limiting factor in the use of gene therapy will remain the application of local delivery systems and gene transfer vectors. Viral vectors and catheter-based local delivery systems seems to provide the best modalities in clinically applicable gene transfer protocols. Joint effort of interventional cardiologists and molecular biologists will provide the required knowledge to make gene transfer a clinical reality.

Original language	English
Title of host publication	CORONARY ARTERY DISEASE: PREVENTION TO INTERVENTION
Editors	BS Lewis, DA Halon, MY Flugelman, P Touboul
Pages	13-17
State	Published - 2000

Keywords

ENDOTHELIAL-CELLS
ARTERIAL-WALL
ANGIOGENESIS

Cite this

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title = "Viral vectors and delivery systems for gene therapy in cardiovascular medicine - The intersection of molecular biology and interventional cardiology",

abstract = "A significant number of patients with syndromes related to arterial obstructive disease cannot benefit from current therapeutic modalities. Theoretically, gene transfer can be used in these and most other patients with cardiovascular disorders. With the completion of the human gene project it can be anticipated that genes relevant to cardiovascular medicine will be identified in the near future. The limiting factor in the use of gene therapy will remain the application of local delivery systems and gene transfer vectors. Viral vectors and catheter-based local delivery systems seems to provide the best modalities in clinically applicable gene transfer protocols. Joint effort of interventional cardiologists and molecular biologists will provide the required knowledge to make gene transfer a clinical reality.",

keywords = "ENDOTHELIAL-CELLS, ARTERIAL-WALL, ANGIOGENESIS",

author = "MY Flugelman and DA Halon and BS Lewis and P Touboul",

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year = "2000",

language = "אנגלית",

isbn = "88-323-0101-6",

pages = "13--17",

editor = "BS Lewis and Halon, {DA } and MY Flugelman and P Touboul",

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}

Viral vectors and delivery systems for gene therapy in cardiovascular medicine - The intersection of molecular biology and interventional cardiology. / Flugelman, MY; Halon, DA; Lewis, BS et al.
CORONARY ARTERY DISEASE: PREVENTION TO INTERVENTION. ed. / BS Lewis; DA Halon; MY Flugelman; P Touboul. 2000. p. 13-17.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Viral vectors and delivery systems for gene therapy in cardiovascular medicine - The intersection of molecular biology and interventional cardiology

AU - Flugelman, MY

AU - Halon, DA

AU - Lewis, BS

A2 - Touboul, P

A2 - Lewis, BS

A2 - Halon, DA

A2 - Flugelman, MY

A2 - Touboul, P

N1 - Times Cited in Web of Science Core Collection: 0 Total Times Cited: 0 Cited Reference Count: 17

PY - 2000

Y1 - 2000

N2 - A significant number of patients with syndromes related to arterial obstructive disease cannot benefit from current therapeutic modalities. Theoretically, gene transfer can be used in these and most other patients with cardiovascular disorders. With the completion of the human gene project it can be anticipated that genes relevant to cardiovascular medicine will be identified in the near future. The limiting factor in the use of gene therapy will remain the application of local delivery systems and gene transfer vectors. Viral vectors and catheter-based local delivery systems seems to provide the best modalities in clinically applicable gene transfer protocols. Joint effort of interventional cardiologists and molecular biologists will provide the required knowledge to make gene transfer a clinical reality.

AB - A significant number of patients with syndromes related to arterial obstructive disease cannot benefit from current therapeutic modalities. Theoretically, gene transfer can be used in these and most other patients with cardiovascular disorders. With the completion of the human gene project it can be anticipated that genes relevant to cardiovascular medicine will be identified in the near future. The limiting factor in the use of gene therapy will remain the application of local delivery systems and gene transfer vectors. Viral vectors and catheter-based local delivery systems seems to provide the best modalities in clinically applicable gene transfer protocols. Joint effort of interventional cardiologists and molecular biologists will provide the required knowledge to make gene transfer a clinical reality.

KW - ENDOTHELIAL-CELLS

KW - ARTERIAL-WALL

KW - ANGIOGENESIS

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SN - 88-323-0101-6

SP - 13

EP - 17

BT - CORONARY ARTERY DISEASE: PREVENTION TO INTERVENTION

ER -

Viral vectors and delivery systems for gene therapy in cardiovascular medicine - The intersection of molecular biology and interventional cardiology

Abstract

Keywords

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