Research output per year
Research output per year
Personal profile
Research interests
Organic Chemistry Applied for the Synthesis, Modifications, and Modulation of Protein Structure and Function
Chemical and Semi-synthesis of Posttranslationally Modified Proteins.
Posttranslational modifications of proteins play crucial roles in health and disease by affecting numerous aspects of protein structure, function, stability and sub-cellular localization...
Studying the Ubiquitin and Ubiquitin Like Modifiers Signals Using Chemical Biology Approaches.
Ubiquitination is the cellular process where a ubiquitin monomer, composed of 76 amino acids, or of a polyubiquitin chain are linked to a protein target,…
Chemical Synthesis of Modified Histones.
Packing the massive DNA polymer into a small and compact size structure within the nucleus is facilitated by nucleosomal proteins known as H2A, H2B, H3…
We are also interested in developing novel strategies to modulate various enzymes using different type of chemical entities. For example, our group is interested in…
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Collaborations and top research areas from the last five years
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Chemical protein synthesis combined with protein cell delivery reveals new insights on the maturation process of SUMO2
Shkolnik, D., Dey, S., Hasan, M., Matunis, M. J. & Brik, A., 2024, (Accepted/In press) In: Chemical Science.Research output: Contribution to journal › Article › peer-review
Open Access -
Exocyclic and Linker Editing of Lys63-linked Ubiquitin Chains Modulators Specifically Inhibits Non-homologous End-joining Repair
Saha, A., Bishara, L. A., Saed, Y., Vamisetti, G. B., Mandal, S., Suga, H., Ayoub, N. & Brik, A., 2024, (Accepted/In press) In: Angewandte Chemie - International Edition.Research output: Contribution to journal › Article › peer-review
Open Access -
Suspension Bead Loading (SBL): An Economical Protein Delivery Platform to Study URM1’s Behavior in Live Cells
Saha, A., Mousa, R., Alalouf, Y., Sadhu, P., Hasan, M., Mandal, S., Mann, G. & Brik, A., 2024, (Accepted/In press) In: Angewandte Chemie - International Edition.Research output: Contribution to journal › Article › peer-review
Open Access -
Basic Residues at Position 11 of α-Conotoxin LvIA Influence Subtype Selectivity between α3β2 and α3β4 Nicotinic Receptors via an Electrostatic Mechanism
Haufe, Y., Kuruva, V., Samanani, Z., Lokaj, G., Kamnesky, G., Shadamarshan, P. K., Shahoei, R., Katz, D., Sampson, J. M., Pusch, M., Brik, A., Nicke, A. & Leffler, A. E., 20 Dec 2023, In: ACS Chemical Neuroscience. 14, 24, p. 4311-4322 12 p.Research output: Contribution to journal › Article › peer-review
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Combining Chemical Protein Synthesis and Random Nonstandard Peptides Integrated Discovery for Modulating Biological Processes
Saha, A., Suga, H. & Brik, A., 18 Jul 2023, In: Accounts of Chemical Research. 56, 14, p. 1953-1965 13 p.Research output: Contribution to journal › Article › peer-review
Open Access