Research output per year
Research output per year
Personal profile
Research interests
Organic Chemistry Applied for the Synthesis, Modifications, and Modulation of Protein Structure and Function
Chemical and Semi-synthesis of Posttranslationally Modified Proteins.
Posttranslational modifications of proteins play crucial roles in health and disease by affecting numerous aspects of protein structure, function, stability and sub-cellular localization...
Studying the Ubiquitin and Ubiquitin Like Modifiers Signals Using Chemical Biology Approaches.
Ubiquitination is the cellular process where a ubiquitin monomer, composed of 76 amino acids, or of a polyubiquitin chain are linked to a protein target,…
Chemical Synthesis of Modified Histones.
Packing the massive DNA polymer into a small and compact size structure within the nucleus is facilitated by nucleosomal proteins known as H2A, H2B, H3…
We are also interested in developing novel strategies to modulate various enzymes using different type of chemical entities. For example, our group is interested in…
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Collaborations and top research areas from the last five years
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Basic Residues at Position 11 of α-Conotoxin LvIA Influence Subtype Selectivity between α3β2 and α3β4 Nicotinic Receptors via an Electrostatic Mechanism
Haufe, Y., Kuruva, V., Samanani, Z., Lokaj, G., Kamnesky, G., Shadamarshan, P. K., Shahoei, R., Katz, D., Sampson, J. M., Pusch, M., Brik, A., Nicke, A. & Leffler, A. E., 20 Dec 2023, In: ACS Chemical Neuroscience. 14, 24, p. 4311-4322 12 p.Research output: Contribution to journal › Article › peer-review
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Combining Chemical Protein Synthesis and Random Nonstandard Peptides Integrated Discovery for Modulating Biological Processes
Saha, A., Suga, H. & Brik, A., 18 Jul 2023, In: Accounts of Chemical Research. 56, 14, p. 1953-1965 13 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Corrigendum to: Structure–Uptake Relationship Study of DABCYL Derivatives Linked to Cyclic Cell-Penetrating Peptides for Live-Cell Delivery of Synthetic Proteins (Angewandte Chemie International Edition, (2022), 61, 47, 10.1002/anie.202207551)
Saha, A., Mandal, S., Arafiles, J. V. V., Gómez-González, J., Hackenberger, C. P. R. & Brik, A., 14 Aug 2023, In: Angewandte Chemie - International Edition. 62, 33, e202307870.Research output: Contribution to journal › Comment/debate
Open Access -
De novo Semi-Synthetic Platform for Monitoring Protein degradation in Live Cells
Hasan, M., Panda, D., Mann, G. & Brik, A., 2023, (Accepted/In press) In: ChemBioChem.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Histone H3 serine-57 is a CHK1 substrate whose phosphorylation affects DNA repair
Parisis, N., Dans, P. D., Jbara, M., Singh, B., Schausi-Tiffoche, D., Molina-Serrano, D., Brun-Heath, I., Hendrychová, D., Maity, S. K., Buitrago, D., Lema, R., Nait Achour, T., Giunta, S., Girardot, M., Talarek, N., Rofidal, V., Danezi, K., Coudreuse, D., Prioleau, M. N., Feil, R., & 5 others, Dec 2023, In: Nature Communications. 14, 1, 5104.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations