Gad Rennert

Prof.

    1985 …2024

    Research activity per year

    Personal profile

    Research interests

    I am a molecular epidemiologist with a particular focus on cancer predisposition, and gene-environment interactions. I have published more than 380 publications on cancer genetics, causation of cancers of the colon, breast, lung, gynecological organs and the pancreato-hepato-biliary system. In addition, I am coordinating the cancer screening activities on a national level in Israel (from policy to implementationadherence, quality testing and outcomes measurement). I am and studying unique founder mutations leading to cancer through the Familial Cancer Consultation Service which I am directing and which cares for some 14000 risk families with thousands of cancer genes mutation carriers, including many patients with Lynch

    Syndrome and the APC I1307K mutation. My work involves a deep epidemiological evaluation of more than 40,000 study participants combined with massive genetic testing using RT-PCR, Sanger sequencing, deep next-generation sequencing, microarray testing, multi-gene expression panels studies, Onco-chip multi-SNP panel, whole exome analysis and other laboratory methods. I have also studied colorectal cancer etiology (including gene-environment interactions) and the role of risk reducing medication in colorectal cancer and other tumors.

         I am involved in the identification of colorectal cancer patients and families with APC I1307K and other benign and pathogenic APC variants. Our population-based studies and clinical service have identified more than 800 carriers of APC 1307K, including 16 homozygotes and more than 100 Lynch Syndrome families with identified mutations in the MMR genes. My population based studies are involved in the CORECT and GECCO consortia of colorectal cancer research where 10,000 of our 14,000 participants in the Molecular Epidemiology of Colorectal Cancer (MECC) Study analyzed by various GWAS platforms, including the recent Illumina 500K OncoArray. Similarly, 4000 samples of our 16000 samples of the BCINIS (Breast Cancer in Northern Israel) Study participated in the NIH Game-On GWAS Initiative through the BCAC and CIMBA consortia and 1500 samples of our 3500 samples of the lung cancer study were studied with GWAS through the ILCCO consortium and we have also contributed ovarian cancer samples through OCAC consortia. We are now in process of testing 10,000 breast cancer samples with the NIH Confluence Project and a deep immunological investigation of a cohort of 1400 women with breast cancer detected before the age of 45, with the use the 770-gene panel of Nanostring (C360).  

    Expertise related to UN Sustainable Development Goals

    In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

    • SDG 3 - Good Health and Well-being

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    • Association between circulating inflammatory markers and adult cancer risk: a Mendelian randomization analysis

      Feb 2024, In: EBioMedicine. 100, p. 104991 104991.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      1 Scopus citations
    • CYP2A6 Activity and Cigarette Consumption Interact in Smoking-Related Lung Cancer Susceptibility

      Du, M., Xin, J., Zheng, R., Yuan, Q., Wang, Z., Liu, H., Liu, H., Cai, G., Albanes, D., Lam, S., Tardon, A., Chen, C., Bojesen, S. E., Landi, M. T., Johansson, M., Risch, A., Bickeboller, H., Wichmann, H. E., Rennert, G. & Arnold, S. & 25 others, Brennan, P., Field, J. K., Shete, S. S., Le Marchand, L., Liu, G., Andrew, A. S., Kiemeney, L. A., Zienolddiny, S., Grankvist, K., Johansson, M., Caporaso, N. E., Cox, A., Hong, Y. C., Yuan, J. M., Schabath, M. B., Aldrich, M. C., Wang, M., Shen, H., Chen, F., Zhang, Z., Hung, R. J., Amos, C. I., Wei, Q., Lazarus, P. & Christiani, D. C., 15 Feb 2024, In: Cancer Research. 84, 4, p. 616-625 10 p.

      Research output: Contribution to journalArticlepeer-review

    • Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes

      Chen, Z., Guo, X., Tao, R., Huyghe, J. R., Law, P. J., Fernandez-Rozadilla, C., Ping, J., Jia, G., Long, J., Li, C., Shen, Q., Xie, Y., Timofeeva, M. N., Thomas, M., Schmit, S. L., Díez-Obrero, V., Devall, M., Moratalla-Navarro, F., Fernandez-Tajes, J. & Palles, C. & 185 others, Sherwood, K., Briggs, S. E. W., Svinti, V., Donnelly, K., Farrington, S. M., Blackmur, J., Vaughan-Shaw, P. G., Shu, X. O., Lu, Y., Broderick, P., Studd, J., Harrison, T. A., Conti, D. V., Schumacher, F. R., Melas, M., Rennert, G., Obón-Santacana, M., Martín-Sánchez, V., Oh, J. H., Kim, J., Jee, S. H., Jung, K. J., Kweon, S. S., Shin, M. H., Shin, A., Ahn, Y. O., Kim, D. H., Oze, I., Wen, W., Matsuo, K., Matsuda, K., Tanikawa, C., Ren, Z., Gao, Y. T., Jia, W. H., Hopper, J. L., Jenkins, M. A., Win, A. K., Pai, R. K., Figueiredo, J. C., Haile, R. W., Gallinger, S., Woods, M. O., Newcomb, P. A., Duggan, D., Cheadle, J. P., Kaplan, R., Kerr, R., Kerr, D., Kirac, I., Böhm, J., Mecklin, J. P., Jousilahti, P., Knekt, P., Aaltonen, L. A., Rissanen, H., Pukkala, E., Eriksson, J. G., Cajuso, T., Hänninen, U., Kondelin, J., Palin, K., Tanskanen, T., Renkonen-Sinisalo, L., Männistö, S., Albanes, D., Weinstein, S. J., Ruiz-Narvaez, E., Palmer, J. R., Buchanan, D. D., Platz, E. A., Visvanathan, K., Ulrich, C. M., Siegel, E., Brezina, S., Gsur, A., Campbell, P. T., Chang-Claude, J., Hoffmeister, M., Brenner, H., Slattery, M. L., Potter, J. D., Tsilidis, K. K., Schulze, M. B., Gunter, M. J., Murphy, N., Castells, A., Castellví-Bel, S., Moreira, L., Arndt, V., Shcherbina, A., Bishop, D. T., Giles, G. G., Southey, M. C., Idos, G. E., McDonnell, K. J., Abu-Ful, Z., Greenson, J. K., Shulman, K., Lejbkowicz, F., Offit, K., Su, Y. R., Steinfelder, R., Keku, T. O., van Guelpen, B., Hudson, T. J., Hampel, H., Pearlman, R., Berndt, S. I., Hayes, R. B., Martinez, M. E., Thomas, S. S., Pharoah, P. D. P., Larsson, S. C., Yen, Y., Lenz, H. J., White, E., Li, L., Doheny, K. F., Pugh, E., Shelford, T., Chan, A. T., Cruz-Correa, M., Lindblom, A., Hunter, D. J., Joshi, A. D., Schafmayer, C., Scacheri, P. C., Kundaje, A., Schoen, R. E., Hampe, J., Stadler, Z. K., Vodicka, P., Vodickova, L., Vymetalkova, V., Edlund, C. K., Gauderman, W. J., Shibata, D., Toland, A., Markowitz, S., Kim, A., Chanock, S. J., van Duijnhoven, F., Feskens, E. J. M., Sakoda, L. C., Gago-Dominguez, M., Wolk, A., Pardini, B., FitzGerald, L. M., Lee, S. C., Ogino, S., Bien, S. A., Kooperberg, C., Li, C. I., Lin, Y., Prentice, R., Qu, C., Bézieau, S., Yamaji, T., Sawada, N., Iwasaki, M., Le Marchand, L., Wu, A. H., Qu, C., McNeil, C. E., Coetzee, G., Hayward, C., Deary, I. J., Harris, S. E., Theodoratou, E., Reid, S., Walker, M., Ooi, L. Y., Lau, K. S., Zhao, H., Hsu, L., Cai, Q., Dunlop, M. G., Gruber, S. B., Houlston, R. S., Moreno, V., Casey, G., Peters, U., Tomlinson, I. & Zheng, W., 26 Apr 2024, In: Nature Communications. 15, 1, p. 3557 3557.

      Research output: Contribution to journalArticlepeer-review

      Open Access
    • Genetic risk impacts the association of menopausal hormone therapy with colorectal cancer risk

      Tian, Y., Lin, Y., Qu, C., Arndt, V., Baurley, J. W., Berndt, S. I., Bien, S. A., Bishop, D. T., Brenner, H., Buchanan, D. D., Budiarto, A., Campbell, P. T., Carreras-Torres, R., Casey, G., Chan, A. T., Chen, R., Chen, X., Conti, D. V., Díez-Obrero, V. & Dimou, N. & 58 others, Drew, D. A., Figueiredo, J. C., Gallinger, S., Giles, G. G., Gruber, S. B., Gunter, M. J., Harlid, S., Harrison, T. A., Hidaka, A., Hoffmeister, M., Huyghe, J. R., Jenkins, M. A., Jordahl, K. M., Joshi, A. D., Keku, T. O., Kawaguchi, E., Kim, A. E., Kundaje, A., Larsson, S. C., Marchand, L. L., Lewinger, J. P., Li, L., Moreno, V., Morrison, J., Murphy, N., Nan, H., Nassir, R., Newcomb, P. A., Obón-Santacana, M., Ogino, S., Ose, J., Pardamean, B., Pellatt, A. J., Peoples, A. R., Platz, E. A., Potter, J. D., Prentice, R. L., Rennert, G., Ruiz-Narvaez, E. A., Sakoda, L. C., Schoen, R. E., Shcherbina, A., Stern, M. C., Su, Y. R., Thibodeau, S. N., Thomas, D. C., Tsilidis, K. K., van Duijnhoven, F. J. B., Van Guelpen, B., Visvanathan, K., White, E., Wolk, A., Woods, M. O., Wu, A. H., Peters, U., Gauderman, W. J., Hsu, L. & Chang-Claude, J., 1 Apr 2024, In: British Journal of Cancer. 130, 10, p. 1687-1696 10 p.

      Research output: Contribution to journalArticlepeer-review

      Open Access
    • Genome-Wide Gene-Environment Interaction Analyses to Understand the Relationship between Red Meat and Processed Meat Intake and Colorectal Cancer Risk

      Sterän, M. C., Mendez, J. S., Kim, A. E., Obón-Santacana, M., Moratalla-Navarro, F., Martín, V., Moreno, V., Lin, Y., Bien, S. A., Qu, C., Su, Y. R., White, E., Harrison, T. A., Huyghe, J. R., Tangen, C. M., Newcomb, P. A., Phipps, A. I., Thomas, C. E., Kawaguchi, E. S. & Lewinger, J. P. & 52 others, Morrison, J. L., Conti, D. V., Wang, J., Thomas, D. C., Platz, E. A., Visvanathan, K., Keku, T. O., Newton, C. C., Um, C. Y., Kundaje, A., Shcherbina, A., Murphy, N., Gunter, M. J., Dimou, N., Papadimitriou, N., Bézieau, S., van Duijnhoven, F. J. B., Mäannistoö, S., Rennert, G., Wolk, A., Hoffmeister, M., Brenner, H., Chang-Claude, J., Tian, Y., Le Marchand, L., Cotterchio, M., Tsilidis, K. K., Bishop, D. T., Melaku, Y. A., Lynch, B. M., Buchanan, D. D., Ulrich, C. M., Ose, J., Peoples, A. R., Pellatt, A. J., Li, L., Devall, M. A. M., Campbell, P. T., Albanes, D., Weinstein, S. J., Berndt, S. I., Gruber, S. B., Ruiz-Narvaez, E., Song, M., Joshi, A. D., Drew, D. A., Petrick, J. L., Chan, A. T., Giannakis, M., Peters, U., Hsu, L. & Gauderman, W. J., 1 Mar 2024, In: Cancer Epidemiology Biomarkers and Prevention. 33, 3, p. 400-410 11 p.

      Research output: Contribution to journalArticlepeer-review