A conformable phased-array ultrasound patch for bladder volume monitoring

Lin Zhang; Colin Marcus; Dabin Lin; David Mejorado; Scott Joseph Schoen; Theodore T. Pierce; Viksit Kumar; Sara V. Fernandez; David Hunt; Qian Li; Ikra Iftekhar Shuvo; David Sadat; Wenya Du; Hannah Edenbaum; Li Jin; Weiguo Liu; Yonina C. Eldar; Fei Li; Anantha P. Chandrakasan; Anthony E. Samir; Canan Dagdeviren

doi:10.1038/s41928-023-01068-x

A conformable phased-array ultrasound patch for bladder volume monitoring

Lin Zhang, Colin Marcus, Dabin Lin, David Mejorado, Scott Joseph Schoen, Theodore T. Pierce, Viksit Kumar, Sara V. Fernandez, David Hunt, Qian Li, Ikra Iftekhar Shuvo, David Sadat, Wenya Du, Hannah Edenbaum, Li Jin, Weiguo Liu, Yonina C. Eldar, Fei Li, Anantha P. Chandrakasan, Anthony E. SamirCanan Dagdeviren

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Ultrasound can be used to image soft tissues in vivo for the early diagnosis and monitoring of disease progression. However, conventional ultrasound probes are rigid, have a narrow field of view and are operator dependent. Conformable transducers have been proposed, but they lack efficient element localization and effective spatial resolution during mechanical deformations. Here we report a conformable ultrasound bladder patch that is based on multiple phased arrays embedded in a stretchable substrate and can provide mechanically robust, conformable and in vivo volumetric organ monitoring. The phased arrays use Sm/La-doped Pb(Mg_1/3Nb_2/3)O₃–PbTiO₃ ceramics as the piezoelectric material, which offers superior properties (d ₃₃ = 1,000 pC N⁻¹, ε _r = 7,500 and k ₃₃ = 0.77) than conventional piezoelectric ceramics. We use the conformable ultrasound patch in a pilot clinical study of bladder monitoring. Bladder volume estimation with the patch is comparable (relative errors of 3.2 ± 6.4% and 10.8 ± 8.2% with and without ultrasound gel, respectively) to that obtained using standard clinical ultrasound equipment, and not requiring manual translation or rotation by an operator.

Original language	English
Pages (from-to)	77-90
Number of pages	14
Journal	Nature Electronics
Volume	7
Issue number	1
DOIs	https://doi.org/10.1038/s41928-023-01068-x
State	Published - Jan 2024
Externally published	Yes

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Instrumentation
Electrical and Electronic Engineering

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10.1038/s41928-023-01068-x

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Zhang, L., Marcus, C., Lin, D., Mejorado, D., Schoen, S. J., Pierce, T. T., Kumar, V., Fernandez, S. V., Hunt, D., Li, Q., Shuvo, I. I., Sadat, D., Du, W., Edenbaum, H., Jin, L., Liu, W., Eldar, Y. C., Li, F., Chandrakasan, A. P., ... Dagdeviren, C. (2024). A conformable phased-array ultrasound patch for bladder volume monitoring. Nature Electronics, 7(1), 77-90. https://doi.org/10.1038/s41928-023-01068-x

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title = "A conformable phased-array ultrasound patch for bladder volume monitoring",

abstract = "Ultrasound can be used to image soft tissues in vivo for the early diagnosis and monitoring of disease progression. However, conventional ultrasound probes are rigid, have a narrow field of view and are operator dependent. Conformable transducers have been proposed, but they lack efficient element localization and effective spatial resolution during mechanical deformations. Here we report a conformable ultrasound bladder patch that is based on multiple phased arrays embedded in a stretchable substrate and can provide mechanically robust, conformable and in vivo volumetric organ monitoring. The phased arrays use Sm/La-doped Pb(Mg1/3Nb2/3)O3–PbTiO3 ceramics as the piezoelectric material, which offers superior properties (d 33 = 1,000 pC N−1, ε r = 7,500 and k 33 = 0.77) than conventional piezoelectric ceramics. We use the conformable ultrasound patch in a pilot clinical study of bladder monitoring. Bladder volume estimation with the patch is comparable (relative errors of 3.2 ± 6.4% and 10.8 ± 8.2% with and without ultrasound gel, respectively) to that obtained using standard clinical ultrasound equipment, and not requiring manual translation or rotation by an operator.",

author = "Lin Zhang and Colin Marcus and Dabin Lin and David Mejorado and Schoen, {Scott Joseph} and Pierce, {Theodore T.} and Viksit Kumar and Fernandez, {Sara V.} and David Hunt and Qian Li and Shuvo, {Ikra Iftekhar} and David Sadat and Wenya Du and Hannah Edenbaum and Li Jin and Weiguo Liu and Eldar, {Yonina C.} and Fei Li and Chandrakasan, {Anantha P.} and Samir, {Anthony E.} and Canan Dagdeviren",

note = "Publisher Copyright: {\textcopyright} 2023, The Author(s), under exclusive licence to Springer Nature Limited.",

year = "2024",

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doi = "10.1038/s41928-023-01068-x",

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Zhang, L, Marcus, C, Lin, D, Mejorado, D, Schoen, SJ, Pierce, TT, Kumar, V, Fernandez, SV, Hunt, D, Li, Q, Shuvo, II, Sadat, D, Du, W, Edenbaum, H, Jin, L, Liu, W, Eldar, YC, Li, F, Chandrakasan, AP, Samir, AE & Dagdeviren, C 2024, 'A conformable phased-array ultrasound patch for bladder volume monitoring', Nature Electronics, vol. 7, no. 1, pp. 77-90. https://doi.org/10.1038/s41928-023-01068-x

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AU - Zhang, Lin

AU - Marcus, Colin

AU - Lin, Dabin

AU - Mejorado, David

AU - Schoen, Scott Joseph

AU - Pierce, Theodore T.

AU - Kumar, Viksit

AU - Fernandez, Sara V.

AU - Hunt, David

AU - Li, Qian

AU - Shuvo, Ikra Iftekhar

AU - Sadat, David

AU - Du, Wenya

AU - Edenbaum, Hannah

AU - Jin, Li

AU - Liu, Weiguo

AU - Eldar, Yonina C.

AU - Li, Fei

AU - Chandrakasan, Anantha P.

AU - Samir, Anthony E.

AU - Dagdeviren, Canan

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AB - Ultrasound can be used to image soft tissues in vivo for the early diagnosis and monitoring of disease progression. However, conventional ultrasound probes are rigid, have a narrow field of view and are operator dependent. Conformable transducers have been proposed, but they lack efficient element localization and effective spatial resolution during mechanical deformations. Here we report a conformable ultrasound bladder patch that is based on multiple phased arrays embedded in a stretchable substrate and can provide mechanically robust, conformable and in vivo volumetric organ monitoring. The phased arrays use Sm/La-doped Pb(Mg1/3Nb2/3)O3–PbTiO3 ceramics as the piezoelectric material, which offers superior properties (d 33 = 1,000 pC N−1, ε r = 7,500 and k 33 = 0.77) than conventional piezoelectric ceramics. We use the conformable ultrasound patch in a pilot clinical study of bladder monitoring. Bladder volume estimation with the patch is comparable (relative errors of 3.2 ± 6.4% and 10.8 ± 8.2% with and without ultrasound gel, respectively) to that obtained using standard clinical ultrasound equipment, and not requiring manual translation or rotation by an operator.

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A conformable phased-array ultrasound patch for bladder volume monitoring

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