TY - JOUR
T1 - Are Metabolites From the Gut Microbiota Capable of Regulating Epigenetic Mechanisms in the Human Parasite Entamoeba histolytica?
AU - Sarid, Lotem
AU - Ankri, Serge
N1 - Copyright © 2022 Sarid and Ankri.
PY - 2022/3/1
Y1 - 2022/3/1
N2 - The unicellular parasite Entamoeba histolytica inhabits the human gut. It has to adapt to a complex environment that consists of the host microbiota, nutritional stress, oxidative stress, and nitrosative stress. Adaptation to this complex environment is vital for the survival of this parasite. Studies have shown that the host microbiota shapes virulence and stress adaptation in E. histolytica. Increasing evidence suggests that metabolites from the microbiota mediate communication between the parasite and microbiota. In this review, we discuss the bacterial metabolites that regulate epigenetic processes in E. histolytica and the implications that this knowledge may have for the development of new anti-amebic strategies.
AB - The unicellular parasite Entamoeba histolytica inhabits the human gut. It has to adapt to a complex environment that consists of the host microbiota, nutritional stress, oxidative stress, and nitrosative stress. Adaptation to this complex environment is vital for the survival of this parasite. Studies have shown that the host microbiota shapes virulence and stress adaptation in E. histolytica. Increasing evidence suggests that metabolites from the microbiota mediate communication between the parasite and microbiota. In this review, we discuss the bacterial metabolites that regulate epigenetic processes in E. histolytica and the implications that this knowledge may have for the development of new anti-amebic strategies.
KW - Entamoeba histolitytica
KW - epitranscriptome/epigenome
KW - gut mcirobiota
KW - metabolites
KW - parasite
KW - epigenome
KW - epitranscriptome
UR - http://www.scopus.com/inward/record.url?scp=85127172257&partnerID=8YFLogxK
U2 - 10.3389/fcell.2022.841586
DO - 10.3389/fcell.2022.841586
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C2 - 35300430
AN - SCOPUS:85127172257
VL - 10
SP - 841586
JO - Frontiers in Cell and Developmental Biology
JF - Frontiers in Cell and Developmental Biology
M1 - 841586
ER -