TY - GEN
T1 - Case Study
T2 - 50th Computing in Cardiology, CinC 2023
AU - Goda, Marton A.
AU - Beloosesky, Ron
AU - David, Chen B.
AU - Weiner, Zeev
AU - Behar, Joachim A.
N1 - Publisher Copyright:
© 2023 CinC.
PY - 2023
Y1 - 2023
N2 - Premature births can lead to complications, with fetal lung immaturity being a primary concern. Currently, fetal lung maturity (FLM) requires an invasive surfactant extraction procedure between the 32nd and 39th weeks of pregnancy. Unfortunately, there is no non-invasive method for FLM assessment. This work hypothesized that fetal breathing movement (FBM) and surfactant levels are inversely coupled and that FBM can serve as a proxy for FLM estimation. To investigate the correlation between FBM and FLM, antenatal corticosteroid (ACS) was administered to increase fetal pulmonary surfactant levels in a high-risk 35th-week pregnant woman showing intrauterine growth restriction. Synchronous sonographic and phonographic measurements were continuously recorded for 25 minutes before and after the ASC treatments. Before the ACS injection, 268 continuous movements FBM episodes were recorded. The number of continuous FBM episodes significantly decreased to 3, 43, and 79 within 24, 48, and 72 hours, respectively, of the first injection of ACS, suggesting an inversely coupled connection between FBM and surfactant level s. Therefore, FBM may serve as a proxy for FLM estimation. Quantitative confirmation of these findings would suggest that FBM measurements could be used as a non-invasive and widely accessible FLM-assessment tool for high-risk pregnancies and routine examinations.
AB - Premature births can lead to complications, with fetal lung immaturity being a primary concern. Currently, fetal lung maturity (FLM) requires an invasive surfactant extraction procedure between the 32nd and 39th weeks of pregnancy. Unfortunately, there is no non-invasive method for FLM assessment. This work hypothesized that fetal breathing movement (FBM) and surfactant levels are inversely coupled and that FBM can serve as a proxy for FLM estimation. To investigate the correlation between FBM and FLM, antenatal corticosteroid (ACS) was administered to increase fetal pulmonary surfactant levels in a high-risk 35th-week pregnant woman showing intrauterine growth restriction. Synchronous sonographic and phonographic measurements were continuously recorded for 25 minutes before and after the ASC treatments. Before the ACS injection, 268 continuous movements FBM episodes were recorded. The number of continuous FBM episodes significantly decreased to 3, 43, and 79 within 24, 48, and 72 hours, respectively, of the first injection of ACS, suggesting an inversely coupled connection between FBM and surfactant level s. Therefore, FBM may serve as a proxy for FLM estimation. Quantitative confirmation of these findings would suggest that FBM measurements could be used as a non-invasive and widely accessible FLM-assessment tool for high-risk pregnancies and routine examinations.
UR - http://www.scopus.com/inward/record.url?scp=85182343693&partnerID=8YFLogxK
U2 - 10.22489/CinC.2023.193
DO - 10.22489/CinC.2023.193
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AN - SCOPUS:85182343693
T3 - Computing in Cardiology
BT - Computing in Cardiology, CinC 2023
Y2 - 1 October 2023 through 4 October 2023
ER -