TY - JOUR
T1 - Characteristics of patients with positional OSA according to ethnicity and the identification of a novel phenotype—lateral positional patients
T2 - a Multi-Ethnic Study of Atherosclerosis (MESA) study
AU - Sason, Yuval Ben
AU - Oksenberg, Arie
AU - Sobel, Jonathan A.
AU - Behar, Joachim A.
N1 - Publisher Copyright:
© 2023 American Academy of Sleep Medicine. All rights reserved.
PY - 2023/3/1
Y1 - 2023/3/1
N2 - Study Objectives: We investigated the characteristics of obstructive sleep apnea (OSA) positional patients’ (PP) phenotypes among different ethnic groups in the Multi-Ethnic Study of Atherosclerosis (MESA) dataset. Moreover, we hypothesized the existence of a new OSA PP phenotype we coined “Lateral PP,” for whom the lateral apnea-hypopnea index is at least double the supine apnea-hypopnea index. Methods: From 2,273 adults with sleep information, we analyzed data of 1,323 participants who slept more than 4 hours and had at least 30 minutes of sleep in both the supine and the nonsupine positions. Demographics and clinical information were compared for the different PP and ethnic groups. Results: 861 (65.1%) patients had OSA, and 35 (4.1%) were Lateral PP. Lateral PP patients were mainly females (62.9%), obese (median body mass index: 31.4 kg/m2), had mild–moderate OSA (94.3%), and mostly were non–Chinese American (97.1%). Among all patients with OSA, 550 (63.9%) were Supine PP and 17.7% were supine-isolated OSA. Supine PP and Lateral PP were present in 73.1% and 1.0% of Chinese Americans, 61.0% and 3.4% of Hispanics, 68.3% and 4.7% of White/Caucasian, and 56.2% and 5.2% of Black/African-American patients with OSA. Conclusions: Chinese Americans have the highest prevalence of Supine PP, whereas Black/African-American patients lean toward less Supine PP and higher Lateral PP. Lateral PP appears to be a novel OSA phenotype. However, Lateral PP was observed in a small group of patients with OSA and thus its existence should be further validated.
AB - Study Objectives: We investigated the characteristics of obstructive sleep apnea (OSA) positional patients’ (PP) phenotypes among different ethnic groups in the Multi-Ethnic Study of Atherosclerosis (MESA) dataset. Moreover, we hypothesized the existence of a new OSA PP phenotype we coined “Lateral PP,” for whom the lateral apnea-hypopnea index is at least double the supine apnea-hypopnea index. Methods: From 2,273 adults with sleep information, we analyzed data of 1,323 participants who slept more than 4 hours and had at least 30 minutes of sleep in both the supine and the nonsupine positions. Demographics and clinical information were compared for the different PP and ethnic groups. Results: 861 (65.1%) patients had OSA, and 35 (4.1%) were Lateral PP. Lateral PP patients were mainly females (62.9%), obese (median body mass index: 31.4 kg/m2), had mild–moderate OSA (94.3%), and mostly were non–Chinese American (97.1%). Among all patients with OSA, 550 (63.9%) were Supine PP and 17.7% were supine-isolated OSA. Supine PP and Lateral PP were present in 73.1% and 1.0% of Chinese Americans, 61.0% and 3.4% of Hispanics, 68.3% and 4.7% of White/Caucasian, and 56.2% and 5.2% of Black/African-American patients with OSA. Conclusions: Chinese Americans have the highest prevalence of Supine PP, whereas Black/African-American patients lean toward less Supine PP and higher Lateral PP. Lateral PP appears to be a novel OSA phenotype. However, Lateral PP was observed in a small group of patients with OSA and thus its existence should be further validated.
KW - ethnicity
KW - lateral positional patients
KW - MESA
KW - OSA
KW - POSA
KW - positional obstructive sleep apnea
KW - positional patients
KW - positional therapy
KW - Humans
KW - Sleep Apnea, Obstructive
KW - Male
KW - Polysomnography
KW - Ethnicity
KW - Sleep
KW - Female
KW - Supine Position
UR - http://www.scopus.com/inward/record.url?scp=85149168981&partnerID=8YFLogxK
U2 - 10.5664/jcsm.10382
DO - 10.5664/jcsm.10382
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C2 - 36533408
AN - SCOPUS:85149168981
SN - 1550-9389
VL - 19
SP - 529
EP - 538
JO - Journal of Clinical Sleep Medicine
JF - Journal of Clinical Sleep Medicine
IS - 3
ER -