Generalized Pustular Psoriasis, Acute Generalized Exanthematous Pustulosis, and Other Pustular Reactions: A Clinical Review

Elisabeth Gössinger; Roni Dodiuk-Gad; Beda Mühleisen; Hazel H. Oon; Choon Chiat Oh; Julia Tatjana Maul; Alexander A. Navarini

doi:10.1016/j.det.2024.01.001

Generalized Pustular Psoriasis, Acute Generalized Exanthematous Pustulosis, and Other Pustular Reactions: A Clinical Review

Elisabeth Gössinger, Roni Dodiuk-Gad, Beda Mühleisen, Hazel H. Oon, Choon Chiat Oh, Julia Tatjana Maul, Alexander A. Navarini

Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

Generalized pustular rashes have various etiologies and can be challenging to diagnose and manage at first presentation. The authors provide an in-depth analysis of common pustular skin eruptions including generalized pustular psoriasis (GPP) and acute generalized exanthematous pustulosis, focusing on their pathophysiology, triggers, clinical presentation, diagnostic challenges, and management strategies. The article also highlights recent advances in genetic research and biologic therapies for GPP and the future directions in personalized medicine and prevention strategies.

Original language	English
Pages (from-to)	317-328
Number of pages	12
Journal	Dermatologic Clinics
Volume	42
Issue number	2
DOIs	https://doi.org/10.1016/j.det.2024.01.001
State	Published - Apr 2024

Keywords

Acute generalized exanthematous pustulosis
Biologic therapies
Drug-induced reactions
Generalized pustular psoriasis
Genetic mutations
IL-36 pathway
Pustular skin eruptions
Acute Disease
Humans
Acute Generalized Exanthematous Pustulosis/diagnosis
Psoriasis/diagnosis
Skin
Skin Diseases, Vesiculobullous/chemically induced
Chronic Disease

ASJC Scopus subject areas

Dermatology

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10.1016/j.det.2024.01.001

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title = "Generalized Pustular Psoriasis, Acute Generalized Exanthematous Pustulosis, and Other Pustular Reactions: A Clinical Review",

abstract = "Generalized pustular rashes have various etiologies and can be challenging to diagnose and manage at first presentation. The authors provide an in-depth analysis of common pustular skin eruptions including generalized pustular psoriasis (GPP) and acute generalized exanthematous pustulosis, focusing on their pathophysiology, triggers, clinical presentation, diagnostic challenges, and management strategies. The article also highlights recent advances in genetic research and biologic therapies for GPP and the future directions in personalized medicine and prevention strategies.",

keywords = "Acute generalized exanthematous pustulosis, Biologic therapies, Drug-induced reactions, Generalized pustular psoriasis, Genetic mutations, IL-36 pathway, Pustular skin eruptions, Acute Disease, Humans, Acute Generalized Exanthematous Pustulosis/diagnosis, Psoriasis/diagnosis, Skin, Skin Diseases, Vesiculobullous/chemically induced, Chronic Disease",

author = "Elisabeth G{\"o}ssinger and Roni Dodiuk-Gad and Beda M{\"u}hleisen and Oon, {Hazel H.} and Oh, {Choon Chiat} and Maul, {Julia Tatjana} and Navarini, {Alexander A.}",

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doi = "10.1016/j.det.2024.01.001",

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AU - Dodiuk-Gad, Roni

AU - Mühleisen, Beda

AU - Oon, Hazel H.

AU - Oh, Choon Chiat

AU - Maul, Julia Tatjana

AU - Navarini, Alexander A.

PY - 2024/4

Y1 - 2024/4

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AB - Generalized pustular rashes have various etiologies and can be challenging to diagnose and manage at first presentation. The authors provide an in-depth analysis of common pustular skin eruptions including generalized pustular psoriasis (GPP) and acute generalized exanthematous pustulosis, focusing on their pathophysiology, triggers, clinical presentation, diagnostic challenges, and management strategies. The article also highlights recent advances in genetic research and biologic therapies for GPP and the future directions in personalized medicine and prevention strategies.

KW - Acute generalized exanthematous pustulosis

KW - Biologic therapies

KW - Drug-induced reactions

KW - Generalized pustular psoriasis

KW - Genetic mutations

KW - IL-36 pathway

KW - Pustular skin eruptions

KW - Acute Disease

KW - Humans

KW - Acute Generalized Exanthematous Pustulosis/diagnosis

KW - Psoriasis/diagnosis

KW - Skin

KW - Skin Diseases, Vesiculobullous/chemically induced

KW - Chronic Disease

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ER -

Generalized Pustular Psoriasis, Acute Generalized Exanthematous Pustulosis, and Other Pustular Reactions: A Clinical Review

Abstract

Keywords

ASJC Scopus subject areas

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