TY - JOUR
T1 - Generalized Pustular Psoriasis, Acute Generalized Exanthematous Pustulosis, and Other Pustular Reactions
T2 - A Clinical Review
AU - Gössinger, Elisabeth
AU - Dodiuk-Gad, Roni
AU - Mühleisen, Beda
AU - Oon, Hazel H.
AU - Oh, Choon Chiat
AU - Maul, Julia Tatjana
AU - Navarini, Alexander A.
N1 - Copyright © 2024 Elsevier Inc. All rights reserved.
PY - 2024/4
Y1 - 2024/4
N2 - Generalized pustular rashes have various etiologies and can be challenging to diagnose and manage at first presentation. The authors provide an in-depth analysis of common pustular skin eruptions including generalized pustular psoriasis (GPP) and acute generalized exanthematous pustulosis, focusing on their pathophysiology, triggers, clinical presentation, diagnostic challenges, and management strategies. The article also highlights recent advances in genetic research and biologic therapies for GPP and the future directions in personalized medicine and prevention strategies.
AB - Generalized pustular rashes have various etiologies and can be challenging to diagnose and manage at first presentation. The authors provide an in-depth analysis of common pustular skin eruptions including generalized pustular psoriasis (GPP) and acute generalized exanthematous pustulosis, focusing on their pathophysiology, triggers, clinical presentation, diagnostic challenges, and management strategies. The article also highlights recent advances in genetic research and biologic therapies for GPP and the future directions in personalized medicine and prevention strategies.
KW - Acute generalized exanthematous pustulosis
KW - Biologic therapies
KW - Drug-induced reactions
KW - Generalized pustular psoriasis
KW - Genetic mutations
KW - IL-36 pathway
KW - Pustular skin eruptions
KW - Acute Disease
KW - Humans
KW - Acute Generalized Exanthematous Pustulosis/diagnosis
KW - Psoriasis/diagnosis
KW - Skin
KW - Skin Diseases, Vesiculobullous/chemically induced
KW - Chronic Disease
UR - http://www.scopus.com/inward/record.url?scp=85186359970&partnerID=8YFLogxK
U2 - 10.1016/j.det.2024.01.001
DO - 10.1016/j.det.2024.01.001
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.systematicreview???
C2 - 38423690
AN - SCOPUS:85186359970
SN - 0733-8635
VL - 42
SP - 317
EP - 328
JO - Dermatologic Clinics
JF - Dermatologic Clinics
IS - 2
ER -