miR-184 represses β-catenin and behaves as a skin tumor suppressor

Lubov Turovsky; Ghazal Kheshaiboun; Gharam Yassen; Sara Nagosa; Ilanit Boyango; Aya Amitai-Lange; Swarnabh Bhattacharya; Neta Ilan; Israel Vlodavsky; Daniel Aberdam; Ruby Shalom-Feuerstein; Emily Avitan-Hersh

doi:10.1038/s41419-024-06554-4

miR-184 represses β-catenin and behaves as a skin tumor suppressor

Lubov Turovsky, Ghazal Kheshaiboun, Gharam Yassen, Sara Nagosa, Ilanit Boyango, Aya Amitai-Lange, Swarnabh Bhattacharya, Neta Ilan, Israel Vlodavsky, Daniel Aberdam, Ruby Shalom-Feuerstein, Emily Avitan-Hersh

Research output: Contribution to journal › Article › peer-review

Abstract

miR-184-knockout mice display perturbed epidermal stem cell differentiation. However, the potential role of miR-184 in skin pathology is unclear. Here, we report that miR-184 controls epidermal stem cell dynamics and that miR-184 ablation enhances skin carcinogenesis in mice. In agreement, repression of miR-184 in human squamous cell carcinoma (SCC) enhances neoplastic hallmarks of human SCC cells in vitro and tumor development in vivo. Characterization of miR-184-regulatory network, suggests that miR-184 inhibits pro-oncogenic pathways, cell proliferation, and epithelial to mesenchymal transformation. Of note, depletion of miR-184 enhances the levels of β-catenin under homeostasis and following experimental skin carcinogenesis. Finally, the repression of β-catenin by miR-184, inhibits the neoplastic phenotype of SCC cells. Taken together, miR-184 behaves as an epidermal tumor suppressor, and may provide a potentially useful target for skin SCC therapy.

Original language	English
Article number	174
Pages (from-to)	174
Journal	Cell Death and Disease
Volume	15
Issue number	2
DOIs	https://doi.org/10.1038/s41419-024-06554-4
State	Published - 26 Feb 2024

Keywords

Animals
Humans
Mice
beta Catenin/genetics
Carcinogenesis/genetics
Carcinoma, Squamous Cell/pathology
Cell Line, Tumor
Cell Movement/genetics
Cell Proliferation/genetics
Gene Expression Regulation, Neoplastic/genetics
MicroRNAs/genetics
Skin Neoplasms/genetics

ASJC Scopus subject areas

Immunology
Cellular and Molecular Neuroscience
Cell Biology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/s41419-024-06554-4

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title = "miR-184 represses β-catenin and behaves as a skin tumor suppressor",

abstract = "miR-184-knockout mice display perturbed epidermal stem cell differentiation. However, the potential role of miR-184 in skin pathology is unclear. Here, we report that miR-184 controls epidermal stem cell dynamics and that miR-184 ablation enhances skin carcinogenesis in mice. In agreement, repression of miR-184 in human squamous cell carcinoma (SCC) enhances neoplastic hallmarks of human SCC cells in vitro and tumor development in vivo. Characterization of miR-184-regulatory network, suggests that miR-184 inhibits pro-oncogenic pathways, cell proliferation, and epithelial to mesenchymal transformation. Of note, depletion of miR-184 enhances the levels of β-catenin under homeostasis and following experimental skin carcinogenesis. Finally, the repression of β-catenin by miR-184, inhibits the neoplastic phenotype of SCC cells. Taken together, miR-184 behaves as an epidermal tumor suppressor, and may provide a potentially useful target for skin SCC therapy.",

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author = "Lubov Turovsky and Ghazal Kheshaiboun and Gharam Yassen and Sara Nagosa and Ilanit Boyango and Aya Amitai-Lange and Swarnabh Bhattacharya and Neta Ilan and Israel Vlodavsky and Daniel Aberdam and Ruby Shalom-Feuerstein and Emily Avitan-Hersh",

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doi = "10.1038/s41419-024-06554-4",

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TY - JOUR

T1 - miR-184 represses β-catenin and behaves as a skin tumor suppressor

AU - Turovsky, Lubov

AU - Kheshaiboun, Ghazal

AU - Yassen, Gharam

AU - Nagosa, Sara

AU - Boyango, Ilanit

AU - Amitai-Lange, Aya

AU - Bhattacharya, Swarnabh

AU - Ilan, Neta

AU - Vlodavsky, Israel

AU - Aberdam, Daniel

AU - Shalom-Feuerstein, Ruby

AU - Avitan-Hersh, Emily

PY - 2024/2/26

Y1 - 2024/2/26

N2 - miR-184-knockout mice display perturbed epidermal stem cell differentiation. However, the potential role of miR-184 in skin pathology is unclear. Here, we report that miR-184 controls epidermal stem cell dynamics and that miR-184 ablation enhances skin carcinogenesis in mice. In agreement, repression of miR-184 in human squamous cell carcinoma (SCC) enhances neoplastic hallmarks of human SCC cells in vitro and tumor development in vivo. Characterization of miR-184-regulatory network, suggests that miR-184 inhibits pro-oncogenic pathways, cell proliferation, and epithelial to mesenchymal transformation. Of note, depletion of miR-184 enhances the levels of β-catenin under homeostasis and following experimental skin carcinogenesis. Finally, the repression of β-catenin by miR-184, inhibits the neoplastic phenotype of SCC cells. Taken together, miR-184 behaves as an epidermal tumor suppressor, and may provide a potentially useful target for skin SCC therapy.

AB - miR-184-knockout mice display perturbed epidermal stem cell differentiation. However, the potential role of miR-184 in skin pathology is unclear. Here, we report that miR-184 controls epidermal stem cell dynamics and that miR-184 ablation enhances skin carcinogenesis in mice. In agreement, repression of miR-184 in human squamous cell carcinoma (SCC) enhances neoplastic hallmarks of human SCC cells in vitro and tumor development in vivo. Characterization of miR-184-regulatory network, suggests that miR-184 inhibits pro-oncogenic pathways, cell proliferation, and epithelial to mesenchymal transformation. Of note, depletion of miR-184 enhances the levels of β-catenin under homeostasis and following experimental skin carcinogenesis. Finally, the repression of β-catenin by miR-184, inhibits the neoplastic phenotype of SCC cells. Taken together, miR-184 behaves as an epidermal tumor suppressor, and may provide a potentially useful target for skin SCC therapy.

KW - Animals

KW - Humans

KW - Mice

KW - beta Catenin/genetics

KW - Carcinogenesis/genetics

KW - Carcinoma, Squamous Cell/pathology

KW - Cell Line, Tumor

KW - Cell Movement/genetics

KW - Cell Proliferation/genetics

KW - Gene Expression Regulation, Neoplastic/genetics

KW - MicroRNAs/genetics

KW - Skin Neoplasms/genetics

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AN - SCOPUS:85186191717

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VL - 15

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JO - Cell Death and Disease

JF - Cell Death and Disease

IS - 2

M1 - 174

ER -

miR-184 represses β-catenin and behaves as a skin tumor suppressor

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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