TY - JOUR
T1 - Positional sleep apnea phenotyping using machine learning and digital oximetry biomarkers
AU - Ben Sason, Yuval
AU - Levy, Jeremy
AU - Oksenberg, Arie
AU - Sobel, Jonathan
AU - Behar, Joachim A.
N1 - Publisher Copyright:
© 2023 Institute of Physics and Engineering in Medicine
PY - 2023/8/1
Y1 - 2023/8/1
N2 - Study Objectives. To examine the feasibility of using digital oximetry biomarkers (OBMs) and body position to identify positional obstructive sleep apnea (POSA) phenotypes. Methods. A multiclass extreme gradient boost (XGBoost) was implemented to classify between three POSA phenotypes, i.e., positional patients (PP), including supine-predominant OSA (spOSA), and supine-isolated OSA (siOSA), and non-positional patients (NPP). A total of 861 individuals with OSA from the multi ethnic study of atherosclerosis (MESA) dataset were included in the study. Overall, 43 OBMs were computed for supine and non-supine positions and used as input features together with demographic and clinical information (META). Feature selection, using mRMR, was implemented, and nested cross validation was used for the model’s performance evaluation. Results. The best performance for the multiclass classification yielded a median weighted F1 of 0.79 with interquartile range (IQR) of 0.06. Binary classification between PP to NPP achieved weighted F1 of 0.87 (0.04). Conclusion. Using OBMs computed in PP and NPP with OSA, it is possible to distinguish between the different phenotypes of POSA. This data-driven algorithm may be embedded in portable home sleep tests.
AB - Study Objectives. To examine the feasibility of using digital oximetry biomarkers (OBMs) and body position to identify positional obstructive sleep apnea (POSA) phenotypes. Methods. A multiclass extreme gradient boost (XGBoost) was implemented to classify between three POSA phenotypes, i.e., positional patients (PP), including supine-predominant OSA (spOSA), and supine-isolated OSA (siOSA), and non-positional patients (NPP). A total of 861 individuals with OSA from the multi ethnic study of atherosclerosis (MESA) dataset were included in the study. Overall, 43 OBMs were computed for supine and non-supine positions and used as input features together with demographic and clinical information (META). Feature selection, using mRMR, was implemented, and nested cross validation was used for the model’s performance evaluation. Results. The best performance for the multiclass classification yielded a median weighted F1 of 0.79 with interquartile range (IQR) of 0.06. Binary classification between PP to NPP achieved weighted F1 of 0.87 (0.04). Conclusion. Using OBMs computed in PP and NPP with OSA, it is possible to distinguish between the different phenotypes of POSA. This data-driven algorithm may be embedded in portable home sleep tests.
KW - digital oximetry biomarkers
KW - obstructive sleep apnea
KW - positional obstructive sleep apnea
UR - http://www.scopus.com/inward/record.url?scp=85167729808&partnerID=8YFLogxK
U2 - 10.1088/1361-6579/accefc
DO - 10.1088/1361-6579/accefc
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AN - SCOPUS:85167729808
SN - 0967-3334
VL - 44
JO - Physiological Measurement
JF - Physiological Measurement
IS - 8
M1 - 085001
ER -