TY - JOUR
T1 - Unraveling the interplay between unicellular parasites and bacterial biofilms
T2 - Implications for disease persistence and antibiotic resistance
AU - Zanditenas, Eva
AU - Ankri, Serge
N1 - Publisher Copyright:
© 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
PY - 2023/12/6
Y1 - 2023/12/6
N2 - Bacterial biofilms have attracted significant attention due to their involvement in persistent infections, food and water contamination, and infrastructure corrosion. This review delves into the intricate interactions between bacterial biofilms and unicellular parasites, shedding light on their impact on biofilm formation, structure, and function. Unicellular parasites, including protozoa, influence bacterial biofilms through grazing activities, leading to adaptive changes in bacterial communities. Moreover, parasites like Leishmania and Giardia can shape biofilm composition in a grazing independent manner, potentially influencing disease outcomes. Biofilms, acting as reservoirs, enable the survival of protozoan parasites against environmental stressors and antimicrobial agents. Furthermore, these biofilms may influence parasite virulence and stress responses, posing challenges in disease treatment. Interactions between unicellular parasites and fungal-containing biofilms is also discussed, hinting at complex microbial relationships in various ecosystems. Understanding these interactions offers insights into disease mechanisms and antibiotic resistance dissemination, paving the way for innovative therapeutic strategies and ecosystem-level implications.
AB - Bacterial biofilms have attracted significant attention due to their involvement in persistent infections, food and water contamination, and infrastructure corrosion. This review delves into the intricate interactions between bacterial biofilms and unicellular parasites, shedding light on their impact on biofilm formation, structure, and function. Unicellular parasites, including protozoa, influence bacterial biofilms through grazing activities, leading to adaptive changes in bacterial communities. Moreover, parasites like Leishmania and Giardia can shape biofilm composition in a grazing independent manner, potentially influencing disease outcomes. Biofilms, acting as reservoirs, enable the survival of protozoan parasites against environmental stressors and antimicrobial agents. Furthermore, these biofilms may influence parasite virulence and stress responses, posing challenges in disease treatment. Interactions between unicellular parasites and fungal-containing biofilms is also discussed, hinting at complex microbial relationships in various ecosystems. Understanding these interactions offers insights into disease mechanisms and antibiotic resistance dissemination, paving the way for innovative therapeutic strategies and ecosystem-level implications.
KW - Bacterial biofilms
KW - biofilm components
KW - biofilm degradation
KW - extracellular polymeric substances (EPS)
KW - nutrients
KW - unicellular parasite
KW - Parasites
KW - Anti-Infective Agents
KW - Drug Resistance, Microbial
KW - Animals
KW - Biofilms
KW - Ecosystem
KW - Bacteria
UR - http://www.scopus.com/inward/record.url?scp=85179014943&partnerID=8YFLogxK
U2 - 10.1080/21505594.2023.2289775
DO - 10.1080/21505594.2023.2289775
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C2 - 38058008
AN - SCOPUS:85179014943
SN - 2150-5594
VL - 15
JO - Virulence
JF - Virulence
IS - 1
M1 - 2289775
ER -