Research output per year
Research output per year
- 40 results
Search results
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2024
Discovery and Accurate Detection of Rare Nucleic Acid Modifications
Luo, R. J., Chen, H. X., Kong, J. W., Zhang, Z., Ayoub, N. & Luo, G. Z., 2024, (Accepted/In press) In: Israel Journal of Chemistry.Research output: Contribution to journal › Review article › peer-review
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Erratum: Correction for Nebenzahl-Sharon et al., "An Interaction with PARP-1 and Inhibition of Parylation Contribute to Attenuation of DNA Damage Signaling by the Adenovirus E4orf4 Protein" (Journal of virology (2019) 93 19)
Nebenzahl-Sharon, K., Sharf, R., Amer, J., Shalata, H., Khoury-Haddad, H., Sohn, S. Y., Ayoub, N., Hearing, P. & Kleinberger, T., 16 Apr 2024, In: Journal of Virology. 98, 4, p. e0027724Research output: Contribution to journal › Comment/debate
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Exocyclic and Linker Editing of Lys63-linked Ubiquitin Chains Modulators Specifically Inhibits Non-homologous End-joining Repair
Saha, A., Bishara, L. A., Saed, Y., Vamisetti, G. B., Mandal, S., Suga, H., Ayoub, N. & Brik, A., 2024, (Accepted/In press) In: Angewandte Chemie - International Edition.Research output: Contribution to journal › Article › peer-review
Open Access -
Harnessing DNA replication stress to target RBM10 deficiency in lung adenocarcinoma
Machour, F. E., R. Abu-Zhayia, E., Kamar, J., Barisaac, A. S., Simon, I. & Ayoub, N., Dec 2024, In: Nature Communications. 15, 1, 6417.Research output: Contribution to journal › Article › peer-review
Open Access -
Why are RNA processing factors recruited to DNA double-strand breaks?
Machour, F. E., Barisaac, A. S. & Ayoub, N., 2024, (Accepted/In press) In: Trends in Genetics.Research output: Contribution to journal › Review article › peer-review
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2023
A dual role of RBM42 in modulating splicing and translation of CDKN1A/p21 during DNA damage response
Ben-Oz, B. M., Machour, F. E., Nicola, M., Argoetti, A., Polyak, G., Hanna, R., Kleifeld, O., Mandel-Gutfreund, Y. & Ayoub, N., Dec 2023, In: Nature Communications. 14, 1, 7628.Research output: Contribution to journal › Article › peer-review
Open Access -
Recruitment of RBM6 to DNA Double-Strand Breaks Fosters Homologous Recombination Repair
Awwad, S. W., Darawshe, M. M., Machour, F. E., Arman, I. & Ayoub, N., 2023, In: Molecular and Cellular Biology. 43, 3, p. 130-142 13 p.Research output: Contribution to journal › Article › peer-review
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2022
CDYL1-dependent decrease in lysine crotonylation at DNA double-strand break sites functionally uncouples transcriptional silencing and repair
Abu-Zhayia, E. R., Bishara, L. A., Machour, F. E., Barisaac, A. S., Ben-Oz, B. M. & Ayoub, N., 19 May 2022, In: Molecular Cell. 82, 10, p. 1940-1955.e7Research output: Contribution to journal › Article › peer-review
Open Access -
Selective macrocyclic peptide modulators of Lys63-linked ubiquitin chains disrupt DNA damage repair
Vamisetti, G. B., Saha, A., Huang, Y. J., Vanjari, R., Mann, G., Gutbrod, J., Ayoub, N., Suga, H. & Brik, A., Dec 2022, In: Nature Communications. 13, 1, 6174.Research output: Contribution to journal › Article › peer-review
Open Access -
תיקון מהיר
איוב, נ. & משעור, פ., 2022, In: הטכניון. p. 26-27 2 p.Research output: Contribution to journal › Article
Open Access -
2021
NELF complex fosters BRCA1 and RAD51 recruitment to DNA damage sites and modulates sensitivity to PARP inhibition
Bishara, L. A., Machour, F. E., Awwad, S. W. & Ayoub, N., Jan 2021, In: DNA Repair. 97, 103025.Research output: Contribution to journal › Article › peer-review
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RBM6 splicing factor promotes homologous recombination repair of double-strand breaks and modulates sensitivity to chemotherapeutic drugs
MacHour, F. E., Abu-Zhayia, E. R., Awwad, S. W., Bidany-Mizrahi, T., Meinke, S., Bishara, L. A., Heyd, F., Aqeilan, R. I. & Ayoub, N., 18 Nov 2021, In: Nucleic Acids Research. 49, 20, p. 11708-11727 20 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2020
Transcriptional Regulation at DSBs: Mechanisms and Consequences
Machour, F. E. & Nabieh, A., Dec 2020, In: Trends in Genetics. 36, 12, p. 981-997 17 p.Research output: Contribution to journal › Review article › peer-review
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2019
An interaction with PARP-1 and inhibition of parylation contribute to attenuation of DNA damage signaling by the adenovirus E4orf4 protein
Nebenzahl-Sharon, K., Sharf, R., Amer, J., Shalata, H., Khoury-Haddad, H., Sohn, S. Y., Ayoub, N., Hearing, P. & Kleinberger, T., Oct 2019, In: Journal of Virology. 93, 19, e02253-18.Research output: Contribution to journal › Article › peer-review
Open Access -
Biphasic functional interaction between the adenovirus E4orf4 protein and DNA-PK
Nebenzahl-Sharon, K., Shalata, H., Sharf, R., Amer, J., Khoury-Haddad, H., Sohn, S. Y., Ayoub, N., Hearing, P. & Kleinberger, T., 1 May 2019, In: Journal of Virology. 93, 10, e01365-18.Research output: Contribution to journal › Article › peer-review
Open Access -
HDAC-dependent decrease in histone crotonylation during DNA damage
Abu-Zhayia, E. R., Machour, F. E., Nabieh, A. & Shen, Z., 8 May 2019, In: Journal of Molecular Cell Biology. 11, 9, p. 804-806 3 p.Research output: Contribution to journal › Letter › peer-review
Open Access -
2018
CDYL1 fosters double-strand break-induced transcription silencing and promotes homology-directed repair
Abu-Zhayia, E. R., Awwad, S. W., Ben-Oz, B. M., Khoury-Haddad, H. & Ayoub, N., 1 Aug 2018, In: Journal of Molecular Cell Biology. 10, 4, p. 341-357 17 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2017
A role of human RNase P subunits, Rpp29 and Rpp21, in homology directed-repair of double-strand breaks
Abu-Zhayia, E. R., Khoury-Haddad, H., Guttmann-Raviv, N., Serruya, R., Jarrous, N. & Nabieh, A., 1 Dec 2017, In: Scientific Reports. 7, 1, 1002.Research output: Contribution to journal › Article › peer-review
Open Access -
NELF-E is recruited to DNA double-strand break sites to promote transcriptional repression and repair
Awwad, S. W., Abu-Zhayia, E. R., Guttmann-Raviv, N. & Ayoub, N., May 2017, In: EMBO Reports. 18, 5, p. 745-764 20 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Total chemical synthesis of methylated analogues of histone 3 revealed KDM4D as a potential regulator of H3K79me3
Jbara, M., Guttmann-Raviv, N., Maity, S. K., Ayoub, N., Brik, A. & Nabieh, A., 15 Sep 2017, In: Bioorganic and Medicinal Chemistry. 25, 18, p. 4966-4970 5 p.Research output: Contribution to journal › Article › peer-review
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2015
Overexpression of KDM4 lysine demethylases disrupts the integrity of the DNA mismatch repair pathway
Awwad, S. W. & Ayoub, N., 2015, In: Biology Open. 4, 4, p. 498-504 7 p.Research output: Contribution to journal › Article › peer-review
Open Access -
The emerging role of lysine demethylases in DNA damage response: Dissecting the recruitment mode of KDM4D/JMJD2D to DNA damage sites
Khoury-Haddad, H., Nadar-Ponniah, P. T., Awwad, S. & Ayoub, N., 1 Apr 2015, In: Cell Cycle. 14, 7, p. 950-958 9 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2014
KDM4C (GASC1) lysine demethylase is associated with mitotic chromatin and regulates chromosome segregation during mitosis
Kupershmit, I., Khoury-Haddad, H., Awwad, S. W., Guttmann-Raviv, N. & Ayoub, N., 2 Jun 2014, In: Nucleic Acids Research. 42, 10, p. 6168-6182 15 p.Research output: Contribution to journal › Article › peer-review
Open Access -
PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair
Khoury-Haddad, H., Guttmann-Raviv, N., Ipenberg, I., Huggins, D., Jeyasekharan, A. D. & Nabieh, A., 18 Feb 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 7, p. E728-E737Research output: Contribution to journal › Article › peer-review
Open Access -
RNA-dependent chromatin localization of KDM4D lysine demethylase promotes H3K9me3 demethylation
Zoabi, M., Nadar-Ponniah, P. T., Khoury-Haddad, H., Usaj, M., Budowski-Tal, I., Haran, T., Henn, A., Mandel-Gutfreund, Y. & Ayoub, N., 1 Dec 2014, In: Nucleic acids research. 42, 21, p. 13026-13038 13 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2013
A cancer-associated BRCA2 mutation reveals masked nuclear export signals controlling localization
Jeyasekharan, A. D., Liu, Y., Hattori, H., Pisupati, V., Jonsdottir, A. B., Rajendra, E., Lee, M., Sundaramoorthy, E., Schlachter, S., Kaminski, C. F., Ofir-Rosenfeld, Y., Sato, K., Savill, J., Ayoub, N. & Venkitaraman, A. R., Oct 2013, In: Nature Structural and Molecular Biology. 20, 10, p. 1191-1201 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Heat shock protein 90 (Hsp90) selectively regulates the stability of KDM4B/JMJD2B histone demethylase
Ipenberg, I., Guttmann-Raviv, N., Khoury, H. P., Kupershmit, I. & Nabieh, A., 24 May 2013, In: Journal of Biological Chemistry. 288, 21, p. 14681-14687 7 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2012
A DNA-damage selective role for BRCA1 E3 ligase in claspin ubiquitylation, CHK1 activation, and DNA repair
Sato, K., Sundaramoorthy, E., Rajendra, E., Hattori, H., Jeyasekharan, A. D., Ayoub, N., Schiess, R., Aebersold, R., Nishikawa, H., Sedukhina, A. S., Wada, H., Ohta, T. & Venkitaraman, A. R., 25 Sep 2012, In: Current Biology. 22, 18, p. 1659-1666 8 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2010
DNA damage regulates the mobility of Brca2 within the nucleoplasm of living cells
Jeyasekharan, A. D., Nabieh, A., Mahen, R., Ries, J., Esposito, A., Rajendra, E., Hattori, H., Kulkarni, R. P. & Venkitaraman, A. R., 14 Dec 2010, In: Proceedings of the National Academy of Sciences of the United States of America. 107, 50, p. 21937-21942 6 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2009
Mobilization and recruitment of HP1: a bimodal response to DNA breakage.
Ayoub, N., Jeyasekharan, A. D. & Venkitaraman, A. R., 2009, In: Cell Cycle. 8, 18, p. 2945-2950 6 p.Research output: Contribution to journal › Review article › peer-review
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Mobilization and recruitment of HP1: A bimodal response to DNA breakage
Ayoub, N., Jeyasekharan, A. D. & Venkitaraman, A. R., 15 Sep 2009, In: Cell Cycle. 8, 18, p. 2946-2951 6 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Paving the way for H2AX phosphorylation: Chromatin changes in the DNA damage response
Ayoub, N., Jeyasekharan, A. D., Bernal, J. A. & Venkitaraman, A. R., 15 May 2009, In: Cell Cycle. 8, 10, p. 1494-1500 7 p.Research output: Contribution to journal › Review article › peer-review
Open Access -
The Carboxyl Terminus of Brca2 Links the Disassembly of Rad51 Complexes to Mitotic Entry
Ayoub, N., Rajendra, E., Su, X., Jeyasekharan, A. D., Mahen, R. & Venkitaraman, A. R., 14 Jul 2009, In: Current Biology. 19, 13, p. 1075-1085 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2008
HP1-β mobilization promotes chromatin changes that initiate the DNA damage response
Ayoub, N., Jeyasekharan, A. D., Bernal, J. A. & Venkitaraman, A. R., 29 May 2008, In: Nature. 453, 7195, p. 682-686 5 p.Research output: Contribution to journal › Article › peer-review
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2003
A novel jmjC domain protein modulates heterochromatization in fission yeast
Ayoub, N., Noma, K. I., Isaac, S., Kahan, T., Grewal, S. I. S. & Cohen, A., Jun 2003, In: Molecular and Cellular Biology. 23, 12, p. 4356-4370 15 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2002
Establishment and maintenance of a heterochromatin domain
Hall, I. M., Shankaranarayana, G. D., Noma, K. I., Ayoub, N., Cohen, A. & Grewal, S. I. S., 27 Sep 2002, In: Science. 297, 5590, p. 2232-2237 6 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2000
A fission yeast repression element cooperates with centromere-like sequences and defines a mat silent domain boundary
Ayoub, N., Goldshmidt, I., Lyakhovetsky, R. & Cohen, A., 2000, In: Genetics. 156, 3, p. 983-994 12 p.Research output: Contribution to journal › Article › peer-review
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X inactivation-specific transcript expression in mouse oocytes and zygotes
Avner, R., Wahrman, J., Richler, C., Ayoub, N., Friedmann, A., Laufer, N. & Mitrani-Rosenbaum, S., Jul 2000, In: Molecular Human Reproduction. 6, 7, p. 591-594 4 p.Research output: Contribution to journal › Article › peer-review
Open Access -
1999
Position effect variegation at the mating-type locus of fission yeast: A cis-acting element inhibits covariegated expression of genes in the silent and expressed domains
Ayoub, N., Goldshmidt, I. & Cohen, A., Jun 1999, In: Genetics. 152, 2, p. 495-508 14 p.Research output: Contribution to journal › Article › peer-review
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1997
Xist RNA is associated with the transcriptionally inactive XY body in mammalian male meiosis
Ayoub, N., Richler, C. & Wahrman, J., 1997, In: Chromosoma. 106, 1, p. 1-10 10 p.Research output: Contribution to journal › Article › peer-review